Preliminary Evaluation of Elasmobranch Large Thymic Cells: Possible Phylogenetic Equivalents to Mammalian Thymic Nurse Cells

软骨鱼大胸腺细胞的初步评估：可能与哺乳动物胸腺护士细胞的系统发育等效

• 批准号: 9509105
• 负责人: Catherine Walsh
• 金额: $ 1.8万
• 依托单位: Mote Marine Laboratory
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-15 至 1996-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9509105&HistoricalAwards=false
• 关键词: Preliminary; Evaluation; Elasmobranch; Large; Thymic

MCB 9509105 Catherine Walsh This proposal is designed to provide valuable preliminary data contributing to the long-term goal of characterizing thymic function in cartilaginous fish, the most primitive groups of jawed vertebrates to possess a distinct thymus. The work focuses on the preliminary characterization of possible phylogenetic equivalents of specialized cells identified in mammalian thymi as thymic nurse cells. The thymic nurse cells are suspected to have roles in interthymic T-cell maturation and/or removal of nonfunctional or self reactive thymocytes. The research planning grant will be used to develop a full research proposal to characterize the functional role and evolutionary significance of elasmobranch thymic cells. %%% This project will investigate the evolution of the thymus and the interrelation of cells in the thymus. It will provide evidence to explain how cells acquire different functions in the body of an organism. ***

MCB 9509105 Catherine沃尔什 这项建议的目的是提供有价值的初步数据，有助于长期目标的胸腺功能的软骨鱼，最原始的有颌脊椎动物群体拥有一个独特的胸腺。 这项工作的重点是初步表征可能的系统发育等价物的专门细胞在哺乳动物胸腺护士细胞。 胸腺滋养细胞被怀疑在胸腺间T细胞成熟和/或去除非功能性或自身反应性胸腺细胞中发挥作用。 研究规划补助金将用于制定一个完整的研究提案，以表征板鳃类胸腺细胞的功能作用和进化意义。 本计画将探讨胸腺的演化及胸腺内细胞的相互关系。 它将提供证据来解释细胞如何在生物体中获得不同的功能。 ***