alpha-Silylketone Enolates: Precursors in the Preparation of Diols, Aminoalcohols, Alcohols, and Amines

α-甲硅烷基酮烯醇化物：制备二醇、氨基醇、醇和胺的前体

• 批准号: 9510292
• 负责人: Mary Mader
• 金额: $ 1.8万
• 依托单位: Grinnell College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 1997-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9510292&HistoricalAwards=false
• 关键词: alpha; Silylketone; Enolates; Precursors; Preparation

This RPG in the Organic Synthesis Program to Professor Mader of Grinnell College will be used to elaborate the synthetic potential of alpha silylketone enolates. Model systems for the preparations of diols, aminoalcohols, alcohols and amines will be the initial targets. Subsequent studies will attempt to incorporate chiral auxiliaries thereby generating the chiral analogues to the above types of substrates. The ability to synthesize organic compounds using selective reagents is a very significant methodology. In this proposal not only is the PI planning to make compounds more efficiently, but also to prepare them as their optical analogues. This is very significant regarding drug manufacturing and other industrial processes.

这个RPG在有机合成计划格林内尔教授马德尔 学院将用于阐述阿尔法的合成潜力 甲硅烷基酮烯醇化物。用于制备二醇的模型系统， 氨基醇、醇和胺将是最初的目标。 随后的研究将尝试引入手性助剂， 生成上述类型底物的手性类似物。 使用选择性试剂合成有机化合物的能力是一种 非常重要的方法论。在这份提案中，不仅PI 计划更有效地制造化合物，但也要准备它们， 它们的光学类似物这对毒品来说意义重大。 制造和其他工业过程。