Neural Endopeptidase 24.15: A Model of Extracellular Communication

中枢神经系统中的经典化学信使是简单的分子，一旦释放，就会迅速从发挥作用的部位移走。大脑和其他身体组织也使用被称为多肽的小蛋白质分子作为信使分子，但终止其作用的机制相对未知。Roberts博士和Glucksman博士发现了一种名为EP 24.15的可溶性肽加工和降解酶，并确定了其在修饰肽作用中的潜在作用。然而，这种酶有几个独特的特征，值得注意的是，它不包含一个序列，使它能够通过经典途径分泌，它位于细胞核和细胞表面。这些不寻常的特征构成了医生进行调查的基础。罗伯茨和格鲁克斯曼。他们将研究与EP 24.15分泌有关的细胞间通路，以及缺乏与分泌有关的序列的蛋白质所使用的机制，以确定分泌的目标。这种酶的多种形式已经被确定，这些形式之间的关系将被研究。这些令人兴奋的研究将揭示神经内分泌细胞内肽加工和分泌的新机制，并对分泌生物学具有普遍意义。

IBN-9512113 Roberts, James L. Classical chemical messengers in the central nervous system are simple molecules which upon release are rapidly removed from the site where their actions are exerted. The brain and other bodily tissues also use small protein molecules called peptides as messenger molecules, but the mechanisms in place to terminate their effects are relative unknown. Dr. Roberts and Dr. Glucksman identified a soluble peptide processing and degrading enzyme known as EP 24.15 and established its potential role in modifying peptide actions. However, this enzyme has several unique features, notably that it does not contain a sequence that will allow it to be secreted by classical pathways, and it is located in the nucleus of the cell as well as on the cell surface. These unusual features form the basis for the investigations to be performed by Drs. Roberts and Glucksman. They will examine the intercellular pathway involved in the secretion of EP 24.15 and the mechanisms used by a protein lacking a sequence involved in secretion, to be targeted for secretion. Multiple forms of this enzyme have been identified and the relationship of these forms will be investigated. These exciting studies will reveal novel mechanisms involved in peptide processing and secretion within neuroendocrine cells and have implications for secretory biology, in general.