The BUBR1 pseudokinase in Spindle Checkpoint Activation and Inactivation

纺锤体检查点激活和失活中的 BUBR1 假激酶

• 批准号: 468767
• 负责人: Elowe Sabine
• 金额: $ 70.22万
• 依托单位: Universit Laval
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-09-01 至 2027-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=468767&lang=en
• 关键词: Kinase; Kinetochore; Mitosis; Sac; Spindle

Checkpoints in the cell exist to ensure that cellular processes are accurately accomplished. These mechanisms tend to be essential and when compromised can result in severe consequences for the cell as well as entire organisms. As an example, checkpoints

细胞中存在检查点，以确保细胞过程被准确完成。这些机制往往是必不可少的，一旦受到损害，可能会对细胞和整个生物体造成严重后果。例如，检查点