Brain Sites for CaM Kinase-Mediated Conditioning Defects in Drosophila

果蝇 CaM 激酶介导的条件缺陷的大脑部位

• 批准号: 9513191
• 负责人: Ralph Greenspan
• 金额: $ 18万
• 依托单位: New York University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 1998-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9513191&HistoricalAwards=false
• 关键词: Brain; Sites; CaM; Kinase; Mediated

9513191 Greenspan Innate behavior, such as courtship in the fruit fly, Drosophila melanogaster, is subject to a high degree of genetic control. But some aspects of it are also modifiable through learning. What a male fly learns during courtship is not to waste his time on a female who has already mated and who will consequently not be receptive to him. An enzyme in nerve cells known as the calcium/calmodulin-dependent protein kinase (CaM kinase II) is thought to play an important role in learning and memory. We have developed techniques to alter the activity of this enzyme in vivo and will carry out studies to define what parts of the brain are involved in this example of learned behavior.

小行星9513191 先天行为，如果蝇（Drosophila melanogaster）的求偶行为，受到高度的遗传控制。 但它的某些方面也可以通过学习来改变。 雄蝇在求偶过程中学到的是，不要把时间浪费在已经交配过的雌蝇身上，因为雌蝇不会接受他。 神经细胞中的一种酶被称为钙/钙调蛋白依赖性蛋白激酶（CaM激酶II），被认为在学习和记忆中起重要作用。 我们已经开发出了在体内改变这种酶活性的技术，并将开展研究，以确定大脑的哪些部分参与了这种学习行为的例子。