Photoperiod and Non-Neuronal Brain Cells

光周期和非神经脑细胞

• 批准号: 9514374
• 负责人: Antonio Nunez
• 金额: $ 11.92万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9514374&HistoricalAwards=false
• 关键词: Photoperiod; Non; Neuronal; Brain; Cells

Nunez 9514374 The brain and its cells are unique in their ability to change in response to their internal surroundings and the animal's experiences. This ability to adapt can be demonstrated at the molecular, cellular and behavioral levels. One of the most plastic cells in the brain are not even nerve cells, but are peripherally derived mast cells. The mast cells and glial elements provide an enriched environment in which the nerve cells function. However, much is unknown about the mast cells in brain especially their function and anatomy. Dr. Nunez is assessing the ability of daylength, a strong environmental cue, to alter the anatomy of brain mast cells and their central nervous system location. These investigations lay the foundation for studies on the influence of mast cells on adaptive behaviors and other neurochemical changes. These investigations will provide significant basic information about the interplay between the environment and brain function. This information will then be used to further understand the how environmental factors increase or decrease species survivability in the wild or captivity.

努涅斯9514374 大脑及其细胞具有独特的能力，能够根据其内部环境和动物的经历而改变。 这种适应能力可以在分子、细胞和行为水平上得到证明。 大脑中最具可塑性的细胞之一甚至不是神经细胞，而是外周来源的肥大细胞。 肥大细胞和神经胶质成分为神经细胞的功能提供了丰富的环境。 然而，关于脑内肥大细胞的功能和解剖结构还不清楚。 Nunez博士正在评估日照长度的能力，这是一种强烈的环境线索，可以改变大脑肥大细胞的解剖结构及其中枢神经系统的位置。 这些研究为肥大细胞对适应行为和其他神经化学变化的影响的研究奠定了基础。 这些调查将提供有关环境与大脑功能之间相互作用的重要基本信息。 这些信息将用于进一步了解环境因素如何增加或减少野生或圈养物种的生存能力。