U.S.-Kenya Cooperative Research: Development of the Mitochondrial Electron Transport Chain of Trypanosoma Brucei

该奖项支持西弗吉尼亚大学生物化学系Diana Beattie博士和肯尼亚内罗毕大学生物化学系Job Kiaira博士之间为期一年的合作研究项目。研究人员将合作开展研究，阐明原生动物布鲁氏锥虫线粒体生物发生受到调控的机制。研究人员将建立在长而细长的哺乳动物血流形态向前循环昆虫形态分化过程中电子传递链不同片段出现的时间过程，并检查分化过程中线粒体蛋白质合成的产物。拟议的合作将美国在线粒体生物发生方面的专业知识与肯尼亚在锥虫发展方面的专业知识结合起来。布鲁氏锥虫是牛中锥虫病的病原体。这项研究将为理解分化过程中的电子传递链及其调控提供重要的新见解。

This award supports a one-year collaborative research project between Dr. Diana Beattie, Department of Biochemistry, West Virginia University, and Dr. Job Kiaira, Department of Biochemistry, University of Nairobi, in Kenya. The investigators will collaborate on research to clarify the mechanism by which mitochondrial biogenesis in the protozoan Trypanosoma brucei is regulated. The investigators will establish the time course of the appearance of different segments of the electron transfer chain during the differentiation from long, slender mammalian bloodstream forms into procyclic insect forms and examine the products of mitochondrial protein synthesis during differentiation. The proposed collaboration combines the expertise in mitochondrial biogenesis in the United States with the Kenyan expertise in the development of trypanosomes. T. brucei is the causative agent of trypanosomiasis in cattle. This study will contribute important new insights into the understanding of the electron transport chain and its regulation during differentiation.