Statistical Mechanics of Fluid Bilayers: Lamellar Phases, Vesicles, and Liposomes

流体双层的统计力学：层状相、囊泡和脂质体

• 批准号: 9520808
• 负责人: William Gelbart
• 金额: $ 37.25万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-11-15 至 1999-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9520808&HistoricalAwards=false
• 关键词: Statistical; Mechanics; Fluid; Bilayers; Lamellar

William Gelbart is supported by a grant from the Theoretical and Computational Chemistry Program to continue his studies involving statistical mechanics of fluid bilayers, lamellar phases, vesicles and liposomes. Four specific topics will be addressed: 1) inter vesicle electrostatics and lateral charge inhomogeneities; 2) structure and free energy of bilayer fusion intermediates; 3) coupling between micellar shapes, sizes, and long-range ordering in concentrated surfactant solutions; and 4) response of lipid bilayers to tension, with and without incorporated surfactant. A combination of formal Poisson-Boltzmann theory and computer simulations using molecular dynamics and Monte Carlo techniques will be used in this research. This work impinges directly on several strategically important areas of research including an understanding of cell membranes and drug delivery systems.

威廉·格尔巴特得到了理论和 计算化学计划，继续他的研究，涉及 流体双层、层状相、囊泡和 脂质体。 将讨论四个具体主题：1）囊泡间 静电和横向电荷不均匀性; 2）结构和自由 双层融合中间体的能量; 3）胶束间的耦合 浓缩表面活性剂中的形状、尺寸和长程有序 溶液;和4）脂质双层对张力的反应，有和没有 掺入的表面活性剂。 一种形式的泊松-玻尔兹曼组合 使用分子动力学和蒙特卡罗的理论和计算机模拟 技术将用于这项研究。 这项工作直接影响到几个具有重要战略意义的领域， 研究包括了解细胞膜和药物输送 系统.