Purchase of a Reflectron Maldi-Tof Mass Spectrometer

购买 Reflectron Maldi-Tof 质谱仪

• 批准号: 9520868
• 负责人: Paul Treichel
• 金额: $ 16.61万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-15 至 1996-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9520868&HistoricalAwards=false
• 关键词: Purchase; Reflectron; Maldi; Tof; Mass

This award from the Chemistry Research Instrumentation and Facilities Program will aid in purchasing a Reflectron Matrix-Assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer for the Department of Chemistry at the University of Wisconsin- Madison. The research studies to be performed include the following: (1) Protein Design and Protein Refolding; (2) Analysis of Oligosaccharides and Glycopeptides with a MALDI-TOF Mass Spectrometer; (3) Polymeric Carbohydrate Inhibitors; (4) Applications of MALDI- TOF Mass Spectrometry in Gene Sequencing; (5) Analysis of Peptides with a Reflectron MALDI-TOF Mass Spectrometer; (6) Polymer Interfaces and Dynamics; and (7) Lateral Diffusion of Vinyl Polymers at the A/W Interface and of Star Polymer at the Toluene/Water Interface. Mass Spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic and organometallic molecules. The addition of the technique of electrospray extends the range of MS to protein and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest techniques available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.

这份来自化学研究仪器和设施项目的合同将帮助威斯康星大学麦迪逊分校化学系购买反射矩阵辅助激光解吸/电离（MALDI）飞行时间（TOF）质谱仪。拟进行的研究包括：(1)蛋白质设计和蛋白质再折叠；(2) MALDI-TOF质谱分析低聚糖和糖肽类；(3)高分子碳水化合物抑制剂；(4) MALDI- TOF质谱法在基因测序中的应用；(5) MALDI-TOF质谱分析多肽(6)高分子界面与动力学；(7)乙烯基聚合物在A/W界面和星形聚合物在甲苯/水界面的横向扩散。质谱（MS）是一种用于探测内部结构细节和获得大量有机、生物有机和有机金属分子的分子组成的技术。电喷雾技术的加入将质谱的范围扩展到蛋白质和核酸分子量，远远超出任何其他技术。电喷雾电离结合高分辨率提供了质谱分析的最新技术。它为化学家提供了表征化合物的最有力的工具之一。在质谱法中获得这种能力对于化学许多领域的前沿研究的进行是必不可少的。