University of Washington Engineered Biomaterials (UWEB) Engineering Research Center

9529161 Ratner华盛顿大学工程生物材料工程研究中心(UWEB)成立的主要目的是利用特定的生物识别机制，以开发用于医疗植入物的新一代生物材料，这些材料将以简单、生理正常的方式在体内愈合。新一代生物材料将被开发出来，它可以与特定的细胞受体相互作用，或与适当的蛋白质结合，然后启动所需的生物反应，从而控制愈合。这种方法的直接副产品包括亲和层析载体、生物传感器、无污染表面、炎症操作和细胞培养底物。一个由材料科学家、分子和生物学家、生物分子工程师和医生组成的跨学科团队将在三个独立的主要领域开展合作：(1)新分子材料的设计、合成和表征；(2)调节细胞信号以开发可愈合的生物材料；以及(3)医学应用和愈合。主要的知识进步将主要是在分子水平上理解愈合的生物学，并因此在操纵巨噬细胞的能力方面。技术进步将是在分子水平上设计的材料与人体宏观信号系统的耦合，这将导致根本不同类型的医疗植入物。UWEB将由27家赞助公司在研究计划和技术转让活动中进行合作。行业将以常驻技术研究员的身份参与研究，并将参与不受NSF奖资助的临床研究和测试。该中心将通过新的课程、教学实验室和自定进度的教学大纲，为研究生和本科生提供生命科学和工程方面的综合教育和培训。该大学的K-12和高中推广方案将扩大到包括UWEB的活动。ERC将与NSF支持的ECSEL联盟计划合作。***

9529161 RATNER The Engineering Research Center for Engineered Biomaterials (UWEB) at the University of Washington is established with the primary objective to exploit specific biological recognition mechanisms in order to develop new generation of biomaterials for medical implants that will heal in the body in a facile, physiologically normal manner. A new generation of biomaterials will be developed that can interact with specific cell receptors or bind with appropriate proteins, and then initiate the desired biological responses allowing control of healing. Direct spin-offs from this approach include affinity chromatography supports, biosensors, nonfouling surfaces, manipulation of inflammation and cell culture substrates. An interdisciplinary team of materials scientists, molecular and biologists, biomolecular engineers, and physicians will collaborate in three independent thrust areas: (1) Design, synthesis and characterization of new molecular materials, (2) Modulation of cell signaling to develop biomaterials that heal, and (3) Medical application and healing. The major knowledge advancement will be mainly in the area of understanding the biology of healing at the molecular level and consequently, on the ability to manipulate the macrophage cells. The technology advancement will be the coupling of materials engineered at the molecular level into macroscopic signaling system of the human organism which will lead to radically different kinds of medical implants. The UWEB will begin with twenty seven sponsoring companies collaborating in the research program and technology transfer activities. Industry will participate in research as resident technical fellows, and will be involved in clinical research and testing which will not be funded by the NSF award. The Center will provide integrated education and training in life sciences and engineering to the graduate and undergraduate students through new courses, teaching laboratories, and self-paced t utorials. The University's K-12 and High School Outreach Programs will be expanded to include the activities of the UWEB. The ERC will collaborate with the NSF supported ECSEL Coalition Program. ***