University of Washington Engineered Biomaterials (UWEB) Engineering Research Center

华盛顿大学工程生物材料（UWEB）工程研究中心

• 批准号: 9529161
• 负责人: Buddy Ratner
• 金额: --
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-15 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9529161&HistoricalAwards=false
• 关键词: University; Washington; Engineered; Biomaterials; UWEB

9529161 RATNER The Engineering Research Center for Engineered Biomaterials (UWEB) at the University of Washington is established with the primary objective to exploit specific biological recognition mechanisms in order to develop new generation of biomaterials for medical implants that will heal in the body in a facile, physiologically normal manner. A new generation of biomaterials will be developed that can interact with specific cell receptors or bind with appropriate proteins, and then initiate the desired biological responses allowing control of healing. Direct spin-offs from this approach include affinity chromatography supports, biosensors, nonfouling surfaces, manipulation of inflammation and cell culture substrates. An interdisciplinary team of materials scientists, molecular and biologists, biomolecular engineers, and physicians will collaborate in three independent thrust areas: (1) Design, synthesis and characterization of new molecular materials, (2) Modulation of cell signaling to develop biomaterials that heal, and (3) Medical application and healing. The major knowledge advancement will be mainly in the area of understanding the biology of healing at the molecular level and consequently, on the ability to manipulate the macrophage cells. The technology advancement will be the coupling of materials engineered at the molecular level into macroscopic signaling system of the human organism which will lead to radically different kinds of medical implants. The UWEB will begin with twenty seven sponsoring companies collaborating in the research program and technology transfer activities. Industry will participate in research as resident technical fellows, and will be involved in clinical research and testing which will not be funded by the NSF award. The Center will provide integrated education and training in life sciences and engineering to the graduate and undergraduate students through new courses, teaching laboratories, and self-paced t utorials. The University's K-12 and High School Outreach Programs will be expanded to include the activities of the UWEB. The ERC will collaborate with the NSF supported ECSEL Coalition Program. ***

小行星9529161 华盛顿大学工程生物材料工程研究中心（UWEB）的主要目标是开发特定的生物识别机制，以开发新一代的医用植入物生物材料，这些材料将以简单，生理正常的方式在体内愈合。 将开发新一代生物材料，它们可以与特定的细胞受体相互作用或与适当的蛋白质结合，然后启动所需的生物反应，从而控制愈合。 这种方法的直接副产品包括亲和色谱支持物、生物传感器、无污染表面、炎症操纵和细胞培养基质。 一个由材料科学家，分子和生物学家，生物分子工程师和医生组成的跨学科团队将在三个独立的推力领域合作：（1）新分子材料的设计，合成和表征，（2）调节细胞信号以开发愈合的生物材料，以及（3）医疗应用和愈合。 主要的知识进步将主要是在分子水平上理解愈合生物学的领域，因此，操纵巨噬细胞的能力。 技术进步将是在分子水平上工程化的材料与人体组织的宏观信号系统的耦合，这将导致完全不同种类的医疗植入物。 UWEB开始时，将有27家赞助公司参与研究项目和技术转让活动。 业界将作为常驻技术研究员参与研究，并将参与临床研究和测试，这些研究和测试不会得到NSF奖项的资助。 该中心将通过新课程、教学实验室和自定进度的教程为研究生和本科生提供生命科学和工程方面的综合教育和培训。 大学的K-12和高中外展计划将扩大到包括UWEB的活动。 ERC将与NSF支持的ECSEL联盟计划合作。 ***