KFO 218: Hormonal Regulation of Body Weight Maintenance

KFO 218：维持体重的荷尔蒙调节

• 批准号: 101434729
• 金额: --
• 依托单位: Institut für Experimentelle Pädiatrische Endokrinologie
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/101434729?language=en
• 关键词: KFO; 218; Hormonal; Regulation; Body

Obesity is one of the most prevalent disorders that challenge the health care systems worldwide due to the enormous implications for morbidity, mortality and quality of life of obese individuals. Various strategies, including lifestyle but also pharmacological approaches, have been shown to support or induce weight loss on the short run. However, those strategies usually fail to establish a sustained energy balance at a novel setpoint and do not stabilise body weight on the long-term. In contrast, many individuals regain weight relatively fast and often the post-intervention body weight even increases compared to baseline (weight cycling), a phenomenon, which may be associated with a worse outcome in terms of complications than adiposity itself. Loss of body weight in obese individuals is associated with a paradox counterregulation that reduces energy expenditure. Recent studies demonstrated that hormonal mechanisms contribute significantly to this phenomenon. This coordinated hormonal response favours weight regain and is, therefore, of major importance for the long-term maintenance of body weight. The opportunity to modify endocrine components of weight regain implies therapeutic interventions to improve the success of body weight maintenance. A more detailed and individualised investigation of these counter-regulatory endocrine responses under weight loss are required to translate these findings into hormone-based clinical treatment trials for weight loss maintenance. Further endocrine responses like sex steroids, glucocorticoids and IGF1 have not been studied within this weight-loss-regain paradigm so far. In addition, the modification of those systems by lifestyle modifications such as physical activity or nutrition has not yet been investigated. Therefore, the strategic objective of this Clinical Research Unit is to identify and characterise hormonal mechanisms counterbalancing weight maintenance after a previous period of negative energy balance. The structure of the Clinical Research Unit takes advantage of the expertise in clinical and basic research within the topics of endocrinology and energy homeostasis in the region of Berlin/Potsdam and facilitates the translation of experimental findings to therapeutic approaches resulting in improved weight maintenance and metabolic health.

肥胖症是世界范围内最普遍的疾病之一，由于肥胖个体的发病率、死亡率和生活质量的巨大影响，其挑战着卫生保健系统。各种策略，包括生活方式和药理学方法，已被证明可以在短期内支持或诱导体重减轻。然而，这些策略通常无法在新的设定点上建立持续的能量平衡，并且不能长期稳定体重。相比之下，许多个体相对较快地恢复体重，并且通常干预后体重甚至与基线相比增加（体重循环），这是一种现象，其可能与并发症方面的结果比肥胖本身更差相关。肥胖个体的体重减轻与减少能量消耗的矛盾反调节有关。最近的研究表明，荷尔蒙机制对这种现象有很大的贡献。这种协调的激素反应有利于体重恢复，因此对于长期维持体重至关重要。改变体重恢复的内分泌成分的机会意味着治疗干预，以提高体重维持的成功率。需要对减肥下的这些反调节内分泌反应进行更详细和个性化的调查，以将这些发现转化为基于药物的临床治疗试验，以维持减肥。到目前为止，还没有在这种减肥-恢复范例中研究过性类固醇、糖皮质激素和IGF 1等进一步的内分泌反应。此外，尚未研究通过改变生活方式（如体育活动或营养）来改变这些系统。因此，该临床研究单位的战略目标是在前一段时间的负能量平衡后，确定和消除抵消体重维持的激素机制。临床研究部门的结构利用了柏林/波茨坦地区内分泌学和能量稳态主题的临床和基础研究的专业知识，并促进了实验结果转化为治疗方法，从而改善体重维持和代谢健康。