Pore Engineering of Chromatography Membranes for Bioseparation

生物分离色谱膜的孔隙工程

• 批准号: LP210301317
• 负责人: Prof Xiwang Zhang
• 金额: $ 54.5万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-08-17 至 2026-08-16
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP210301317
• 关键词: Pore; Engineering; Chromatography; Membranes; Bioseparation

Protein separation and purification is an essential unit operation in manufacturing processes of therapeutic proteins. The project aims to advance the practical applications of chromatography membrane, an emerging technology for protein separation and purification, by tailoring membrane pore geometry and surface functionality to achieve enhanced separation performance. The project expects to generate advanced knowledge and techniques in the fields of reactive polymer synthesis, functional membrane fabrication and application in bioseparation. The innovative membranes developed in the project are able to improve the production capacity of therapeutic protein manufacturing processes, providing significant economic benefits to Australia.

蛋白质分离和纯化是治疗蛋白质制造过程中必不可少的单位操作。该项目旨在通过调整膜孔的几何形状和表面功能来提高色谱膜的实际应用，这是一种新兴的蛋白质分离和纯化技术，以实现增强的分离性能。该项目预计将在反应性聚合物合成，功能性膜制造以及在生物序列中的应用中产生高级知识和技术。该项目中开发的创新膜能够提高治疗性蛋白质制造工艺的生产能力，从而为澳大利亚带来巨大的经济利益。