U.S.-French Cooperative Research: Structural and Functional Studies of Inhibition of Acetylcholinesterase by Fasciculin

这三年的美国奖-法国结构生物学合作研究涉及 位于圣地亚哥的加州大学的帕尔默·泰勒和来自 法国马赛的艾克斯大学马赛第二分校。 他们研究的目的是 研究乙酰胆碱酯酶（AChE）及其神经毒素的相互作用， 抑制纤维束蛋白2。 他们建议获得脱辅基酶的晶体并分析其组成。 酶-毒素相互作用的动力学。 该项目利用互补性 美国和法国调查人员的专业知识，并提供同步加速器设施 在法国 它将促进我们对酶之间相互作用模式的理解 和毒素。

This three-year award for U.S.-France cooperative research in structural biology involves Palmer Taylor of the University of California at San Diego and Pascale Marchot of the University of Aix Marseille II in Marseille, France. The objective of their research is to investigate the interaction of the enzyme acetylcholinesterase (AChE) and its neurotoxin, inhibitor fasciculin 2. They propose to obtain a crystal of the apoenzyme and analyze the kinetics of the enzyme-toxin interaction. The project takes advantage of complementary expertise of the U.S. and French investigators and provides access to synchrotron facilities in France. It will advance our understanding of the mode of interaction between enzymes and toxins.