Metal-Catalyzed Alpha Amination

本研究的重点是开发直接金属催化的胺化反应。本研究的目的包括探讨铁催化胺化反应的机理和合成范围，以及利用手性铁配合物开发对映选择性反应。研究了Fe-、Ru-和al-二氧化氮配合物的一般反应活性，并对选定的金属-亚胺配合物L2M(=NR)2 （M=Cr,Mo，W）作为潜在的胺化剂和催化剂进行了评价。以硝基烷烃为胺化剂的新型金属促进烯丙基胺化反应的研究也将进行。有了这个奖项，合成有机项目支持了俄克拉何马大学化学系的肯尼斯·m·尼古拉斯博士的研究。尼古拉斯教授将致力于开发将氮基官能团直接引入不饱和含碳化合物的新方法。含氮化合物是制备许多药物、阳离子表面活性剂甚至织物柔软剂的基本成分

The focus of this research is the development of direct metal-catalyzed amination reactions. Goals of the present work include probing the mechanism and synthetic scope of Fe-catalyzed amination and the development of enantioselective reactions via the use of chiral iron complexes. The general reactivity of Fe-, Ru- and Al-azodioxide complexes will be explored and selected metal-imido complexes, L2M(=NR)2 (M=Cr,Mo,W) will be evaluated as potential amination agents and catalysts. Investigation of novel metal-promoted allylic aminations using nitroalkanes as aminating agents will also be carried out. With this award, the Synthetic Organic Program is supporting the research of Dr. Kenneth M. Nicholas of the Department of Chemistry at the University of Oklahoma. Professor Nicholas will focus his work on developing new methods for the direct introduction of nitrogen-based functional groups into unsaturated carbon containing compounds. Nitrogen containing compounds form the building blocks for the preparation of numerous pharmaceuticals , cationic surfactants and even fabric softeners