Manganese(III)acetate promoted and palladium- and gold-catalysed cyclisation reactions of malonates towards the synthesis of oxazolomycins

在该项目的范围内，将开发恶唑霉素的合成。这些天然产物表现出有趣的生物学和药理学特性，即抗菌、抗病毒和抗肿瘤活性。到目前为止，只发表了两个关于这一系列天然产品的单一成员的合成。对于综合，将应用两种一般策略。首先，研究了锰(III)催化丙二酸氧化自由基环化反应的可行性。其次，研究过渡金属催化丙二酸酯及其衍生物与烯烃或炔烃的分子内环化反应的方法。该项目这一部分的目的是确定对模型系统进行所需转换的可行性，然后将其应用于恶唑霉素家族成员的合成。

Within the scope of this project a synthesis of the oxazolomycins will be developed. These natural products exhibit interesting biological and pharmacological properties, namely antibiotic, antiviral and antitumor activity. Up to date only two syntheses are published of a single member of this family of natural products. For the synthesis two general strategies will be applied. Firstly, the feasibility of the manganese(III) mediated oxidative radical cyclisations of malonates will be investigated. Secondly, a method for transition metal-catalysed intramolecular cyclisation reaction of malonates or derivatives with alkenes or alkynes will be studied. The aim of this part of the project is to establish the feasibility of the required transformations on model systems followed by its application to the synthesis of members of the oxazolomycin family.