Manganese(III)acetate promoted and palladium- and gold-catalysed cyclisation reactions of malonates towards the synthesis of oxazolomycins

乙酸锰(III)促进钯和金催化的丙二酸环化反应以合成恶唑霉素

• 批准号: 106209212
• 负责人: Dr. Wilfried Hess
• 金额: --
• 依托单位: Department of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/106209212?language=en
• 关键词: Manganese; III; acetate; promoted; palladium

Within the scope of this project a synthesis of the oxazolomycins will be developed. These natural products exhibit interesting biological and pharmacological properties, namely antibiotic, antiviral and antitumor activity. Up to date only two syntheses are published of a single member of this family of natural products. For the synthesis two general strategies will be applied. Firstly, the feasibility of the manganese(III) mediated oxidative radical cyclisations of malonates will be investigated. Secondly, a method for transition metal-catalysed intramolecular cyclisation reaction of malonates or derivatives with alkenes or alkynes will be studied. The aim of this part of the project is to establish the feasibility of the required transformations on model systems followed by its application to the synthesis of members of the oxazolomycin family.

在本项目范围内，将开发恶唑霉素的合成。这些天然产物表现出有趣的生物学和药理学性质，即抗生素、抗病毒和抗肿瘤活性。迄今为止，只有两个合成发表的一个单一的成员，这一家庭的天然产物。对于合成，将应用两个一般策略。首先，将研究锰（III）介导的丙二酸酯的氧化自由基环化的可行性。其次，研究了过渡金属催化的丙二酸酯及其衍生物与烯烃或炔的分子内环化反应。该项目的这一部分的目的是建立模型系统所需的转换的可行性，然后将其应用于恶唑霉素家族成员的合成。