Lipid-protein interactions underlying mechanosensitivity in K2P K+ channels (A03)

在前一个资助期收集的专业知识的基础上，当前项目的目标将是阐明K2P钾通道的机械敏感门控机制，涉及生理学和病理生理学，例如温度和疼痛的感觉。我们计划将计算电生理模拟与外加膜应力相结合，以诱导机械敏感门控并揭示其潜在机制。基于模拟的假设将在与SFB内部合作伙伴以及外部合作伙伴的合作下进行实验验证。

Building up on the expertise gathered in the previous funding period, the goal of the current project will be to elucidate the mechanism of mechanosensitive gating of K2P potassium channels, involved in the physiology and pathophysiology of e.g., the sensation of temperature and pain. We plan to combine computational electrophysiology simulations with applied membrane stress to induce mechanosensitive gating and to unravel the underlying mechanism. The hypotheses based on the simulations will be validated experimentally in collaboration with partners within the SFB as well as with external collaboration partners.