Dissertation Research: The Effect of Metabolic Rate on Mitochondrial DNA Evolution in the Tenrecidae (Insectivora: Mammalia)

论文研究：代谢率对跳蚤科（食虫目：哺乳动物）线粒体 DNA 进化的影响

• 批准号: 9623454
• 负责人: Bruce Patterson
• 金额: $ 0.75万
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9623454&HistoricalAwards=false
• 关键词: Dissertation; Research; Effect; Metabolic; Rate

9623454 Patterson The genetic code is "degenerate," because not all changes in genetic structure are accompanied by changes in the proteins they produce. Base-pair substitutions at "silent" coding sites of mitichondrial DNA are known to deviate from the constant mutation rates predicted by population genetic theory. Some researchers hypothesize that higher metabolic rates produce higher (and therefore unequal) rates of DNA mutation. A little-known family of mammalian insectivores, the tenrecs of Madagascar and Africa, exhibit a wide range of metabolic rates and is thus especially well suited for testing this hypothesis for unequal evolutionary rates. The evolutionary relationships of the tenrecs will be established using independent morphological and genetic information, including nuclear DNA sequences. The evolution of metabolic rates and their effects on mitochondrial DNA substitutions will be assessed against this evolutionary tree, providing a powerful empirical test of theoretical predictions.

小行星9623454 遗传密码是“简并的”，因为并非所有遗传结构的变化都伴随着它们产生的蛋白质的变化。 已知在哺乳动物DNA的“沉默”编码位点处的碱基对替换偏离群体遗传学理论预测的恒定突变率。 一些研究人员假设，较高的代谢率产生较高的（因此不平等的）DNA突变率。 马达加斯加和非洲的马岛猕猴是一个鲜为人知的食虫哺乳动物家族，它们的代谢率变化范围很大，因此特别适合检验这种进化率不等的假设。 进化 的关系 的 马岛猬 将 使用独立的形态学和遗传信息，包括核DNA序列。代谢率的演变及其对线粒体DNA取代的影响将根据这一进化树进行评估，为理论预测提供了一个强有力的实证检验。