CAREER: Polysaccharide Composite Materials for Engineering of Vascular Tissue

职业：用于血管组织工程的多糖复合材料

• 批准号: 9624151
• 负责人: Howard Matthew
• 金额: $ 30.7万
• 依托单位: Wayne State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-15 至 2000-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9624151&HistoricalAwards=false
• 关键词: CAREER; Polysaccharide; Composite; Materials; Engineering

9624151 Matthew This career development plan contains both research and education activities. The objective of the research is the development of cell-seeded tubular prostheses that will allow for the proliferation of smooth muscle in its matrix and endothelial cells on its luminal surface. The primary chemical constituent of the matrix will be glycosamioglycans, a biologically active polysaccharide from connective tissues. The research will focus on characterizing the physicochemical properties of the prostheses, evaluation of the growth of vascular cells on these materials, and the development of a simulated in vitro system for overall evaluation. The goal of the education plan is to engage in curriculum development with an emphasis on Problem-Based Learning and Group Learning, and to foster minority student recruitment, retention and mentoring activities. ***

9624151马修这个职业发展计划包含研究和教育活动。 该研究的目的是开发细胞接种的管状假体，该假体将允许其基质中的平滑肌和其管腔表面上的内皮细胞增殖。 基质的主要化学成分是糖胺聚糖，一种来自结缔组织的生物活性多糖。 该研究将侧重于表征假体的物理化学性质，评估血管细胞在这些材料上的生长，以及开发用于整体评估的模拟体外系统。 教育计划的目标是参与课程编制，重点是基于问题的学习和小组学习，并促进少数民族学生的招收、保留和辅导活动。 ***