CAREER: Receptor-Mediated Bacterial Adhesion to Extra- cellular Matrix

9702985 Ross 该提案的研究部分旨在了解细菌细胞和胶原细胞外基质之间的细胞粘附过程。 最终目标是更好地了解细菌性疾病的发生过程。 PI 的假设是，S.sureus 在生理流动条件下粘附胶原蛋白的能力与细菌上胶原蛋白受体的数量直接相关。 因此，将确定胶原蛋白受体的数量，测量细胞粘附，并测试相关性。 还将确定流体剪切对受体表达的影响。 该教育计划的重点是增加女性在工程行业的参与。 具有学术才华的年轻女性将从高中开始接受本科工程培训。 将为大三和大四学生提供研究机会。 ***

9702985 Ross The research portion this proposal is directed toward an understanding of the cell adhesion process between bacterial cells and collagen extracellular matrices. The ultimate goal is to better understand the bacterial disease initiation process. The PI's hypothesis is that the ability of S. sureus to adhere to collagen under physiological flow conditions is directly related to the number of collagen receptors on the bacteria. Thus, the number of collagen receptors will be determined, the cell adhesion measured, and the correlation tested. The impact of fluid shear on receptor expression will also be determined. The educational plan centers around increasing the participation of women in the engineering profession. Academically talented young women will be coached from high school through their undergraduate engineering training. Research opportunities will be developed for juniors and seniors. ***