CAREER: Receptor-Mediated Bacterial Adhesion to Extra- cellular Matrix

职业：受体介导的细菌粘附到细胞外基质

• 批准号: 9702985
• 负责人: Julia Ross
• 金额: $ 20万
• 依托单位: University of Maryland Baltimore County
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9702985&HistoricalAwards=false
• 关键词: CAREER; Receptor; Mediated; Bacterial; Adhesion

9702985 Ross The research portion this proposal is directed toward an understanding of the cell adhesion process between bacterial cells and collagen extracellular matrices. The ultimate goal is to better understand the bacterial disease initiation process. The PI's hypothesis is that the ability of S. sureus to adhere to collagen under physiological flow conditions is directly related to the number of collagen receptors on the bacteria. Thus, the number of collagen receptors will be determined, the cell adhesion measured, and the correlation tested. The impact of fluid shear on receptor expression will also be determined. The educational plan centers around increasing the participation of women in the engineering profession. Academically talented young women will be coached from high school through their undergraduate engineering training. Research opportunities will be developed for juniors and seniors. ***

9702985 Ross该研究部分旨在了解细菌细胞与胶原细胞外基质之间的细胞粘附过程。 最终目标是更好地了解细菌性疾病的启动过程。 PI的假设是S.在生理流动条件下粘附于胶原的粘附力与细菌上的胶原受体的数量直接相关。 因此，将确定胶原蛋白受体的数量，测量细胞粘附，并测试相关性。 还将确定流体剪切对受体表达的影响。 教育计划的中心是增加妇女在工程专业的参与。 学术上有才华的年轻女性将从高中开始接受指导，直到本科工程培训。 将为大三和大四学生提供研究机会。 ***