CAREER: Receptor-Mediated Bacterial Adhesion to Extra- cellular Matrix

9702985罗斯研究部分本建议旨在了解细菌细胞和胶原细胞外基质之间的细胞黏附过程。最终目标是更好地了解细菌疾病的启动过程。PI的假设是，在生理流动条件下，苏氏链球菌与胶原蛋白的黏附能力与细菌上胶原蛋白受体的数量直接相关。因此，将确定胶原受体的数量，测量细胞粘附性，并检验相关性。流体剪切对受体表达的影响也将被确定。教育计划的核心是增加女性在工程专业的参与度。有学术天赋的年轻女性将从高中开始接受本科工程培训。将为三年级和四年级学生开发研究机会。***

9702985 Ross The research portion this proposal is directed toward an understanding of the cell adhesion process between bacterial cells and collagen extracellular matrices. The ultimate goal is to better understand the bacterial disease initiation process. The PI's hypothesis is that the ability of S. sureus to adhere to collagen under physiological flow conditions is directly related to the number of collagen receptors on the bacteria. Thus, the number of collagen receptors will be determined, the cell adhesion measured, and the correlation tested. The impact of fluid shear on receptor expression will also be determined. The educational plan centers around increasing the participation of women in the engineering profession. Academically talented young women will be coached from high school through their undergraduate engineering training. Research opportunities will be developed for juniors and seniors. ***