Transcutaneous Laser Doppler Measurement of Mucus Clearance

经皮激光多普勒测量粘液清除率

• 批准号: 9704180
• 负责人: Stanley Yamashiro
• 金额: $ 2.02万
• 依托单位: University of Southern California
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-15 至 1999-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9704180&HistoricalAwards=false
• 关键词: Transcutaneous; Laser; Doppler; Measurement; Mucus

9704180YamashiroMucus elimination is a major problem faced by patients with lung diseases such as cystic fibrosis. Development of effective therapies and assist devices for enhancing mucus removal is greatly hindered by the lack of a reliable non-invasive method of measuring mucus clearance in the airways. Currently, drug doses, assist devices, and physical therapy strategies cannot be optimized for a particular patient due to the lack of this capability. The situation is analogous to trying to treat hypertension without periodic blood pressure measurements. A non-invasive transcutaneous (through the skin) laser doppler method is proposed where a low power laser beam is directed into the airway in the neck region to measure the velocity of the moving mucus layer. Signal processing techniques will be developed to discriminate mucus layer reflections from those from skin and tissue. Initial evaluation will be made using a mechanical model of mucus flow and tissue perfusion.***

9704180Yamashiro 粘液消除是囊性纤维化等肺部疾病患者面临的主要问题。 由于缺乏可靠的非侵入性测量气道粘液清除率的方法，极大地阻碍了用于增强粘液清除的有效疗法和辅助装置的开发。 目前，由于缺乏这种能力，药物剂量、辅助设备和物理治疗策略无法针对特定患者进行优化。 这种情况类似于尝试在不定期测量血压的情况下治疗高血压。 提出了一种非侵入性经皮（穿过皮肤）激光多普勒方法，其中将低功率激光束引导到颈部区域的气道中以测量移动粘液层的速度。 将开发信号处理技术来区分粘液层反射与皮肤和组织反射。将使用粘液流动和组织灌注的机械模型进行初步评估。***