Interference of the viral effector proteins pp71 and IE1 with ND10-mediated intrinsic immunity against human cytomegalovirus infections (B03)

我们已经证明了一种特定的细胞核细胞器，称为PML核体（PML- nb），被病毒效应蛋白如人巨细胞病毒的pp71-或ie1 -蛋白修饰。这与作为细胞限制因子的PML-NB组分的直接抑制功能的拮抗有关。最近的研究揭示了PML-NBs作为进一步先天反应（例如IFN通路）的共同调节结构的新作用。本研究探讨了IE1和pp71如何能够逃避由TRIM因子控制的内在和先天免疫反应。

We have demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB), is modified by viral effector proteins such as the pp71- or IE1-protein of human cytomegalovirus. This correlates with antagonization of a direct repressive function of PML-NB components that act as cellular restriction factors. Recent studies reveal an emerging role of PML-NBs as co-regulatory structures of further innate responses (e.g. IFN pathway). This proposal investigates how IE1 and pp71 are able to evade intrinsic and innate immune responses particularly governed by TRIM factors.