Interference of the viral effector proteins pp71 and IE1 with ND10-mediated intrinsic immunity against human cytomegalovirus infections (B03)

病毒效应蛋白 pp71 和 IE1 对 ND10 介导的针对人类巨细胞病毒感染的内在免疫的干扰 (B03)

• 批准号: 114236576
• 金额: --
• 依托单位: Institut für Virologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/114236576?language=en
• 关键词: Interference; viral; effector; proteins; pp71

We have demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB), is modified by viral effector proteins such as the pp71- or IE1-protein of human cytomegalovirus. This correlates with antagonization of a direct repressive function of PML-NB components that act as cellular restriction factors. Recent studies reveal an emerging role of PML-NBs as co-regulatory structures of further innate responses (e.g. IFN pathway). This proposal investigates how IE1 and pp71 are able to evade intrinsic and innate immune responses particularly governed by TRIM factors.

我们已经证明了细胞核的一个特殊细胞器，称为PML核体(PML-NB)，被病毒效应蛋白如人巨细胞病毒的pp71-或IE1-蛋白修饰。这与作为细胞限制因子的PML-NB组分的直接抑制功能的抗凝有关。最近的研究表明，PML-NBS作为进一步的先天反应(如干扰素途径)的共同调节结构而出现了新的作用。这项建议调查了IE1和pp71如何能够逃避固有和先天免疫反应，特别是由修剪因子控制的。