CAREER: Enhancement of Minority Research Opportunities Through the Full Integration of Research and Teaching Experiences

前列腺素（Prostaglandins）是一类环脂肪酸，是多种生物体内关键生理过程的有效介质。前列腺素是通过磷脂酶A2 （PLA2）和/或磷脂酶C （placc）和环氧化酶（COX）的顺序作用在细胞膜上连续合成的。PLA2 /PLAC介导花生四烯酸从膜磷脂的sn-2位置释放。COX将两分子氧结合到花生四烯酸中，并伴随碳链的环化产生前列腺素。已知有两个基因编码COX，一个构成型COX1基因和一个诱导型早期反应COX2基因。本研究将确定在COX1基因启动子和COX1 mRNA水平上调控前列腺素合成的分子机制。该项目的教育部分包括利用该研究项目进一步发展马萨诸塞州湾社区学院非传统和少数民族学生的生物技术项目，开发涉及马萨诸塞州湾社区学院、波士顿新英格兰水族馆和巴西亚马逊大学的相关海洋生物技术项目；并为波士顿公立学校系统的小学生和教师开发一项科学充实计划。前列腺素是一个环状脂肪酸家族，在许多物种中是关键生理过程的有效介质。本研究将确定在COX1基因水平上调控前列腺素合成的分子机制。该项目的教育部分包括使用该研究计划进一步发展麻省湾社区学院非传统和少数民族学生的生物技术计划；制定相关的海洋生物技术计划，包括马萨诸塞湾社区学院、波士顿的新英格兰水族馆和巴西的亚马逊大学；并为波士顿公立学校系统的小学生和教师开发一项科学充实计划。＊＊＊

9707644 Jackson Prostaglandins are a family of cyclic fatty acids which are potent mediators of key physiological processes in a large variety of organisms. Prostaglandins are continuously synthesized in cell membranes by the sequential action of the key regulatory enzymes phospholipase A2 (PLA2) and/or phospholipase C (PLAC), and cyclooxygenase (COX). PLA2 /PLAC mediate the release of arachidonic acid from the sn-2 position of membrane phospholipids. COX incorporates two molecules of oxygen into arachidonic acid concomitant with the cyclization of the carbon chain to produce prostaglandin. Two genes are known to encode COX, a constitutive COX1 gene and an inducible, early-response COX2 gene. This research will determine the molecular mechanisms that regulate prostaglandin synthesis at the level of the COX1 gene promoter and COX1 mRNA. The education portion of this project includes using this research program to further develop the Biotechnology Program for non-traditional and minority students at Massachusetts Bay Community College, to develop a related Marine Biotechnology Program involving Massachusetts Bay Community College, the New England Aquarium in Boston, and The University of the Amazon in Brazil; and to develop a science enrichment program for primary school students and teachers in the Boston Public School system. %%% Prostaglandins are a family of cyclic fatty acids which are potent mediators of key physiological processes in a large variety of species. This research will determine the molecular mechanisms that regulate prostaglandin synthesis at the level of the COX1 gene. The education portion of this project includes using this research program to further develop the Biotechnology Program for non-traditional and minority students at Massachusetts Bay Community College; to develop a related Marine Biotechnology Program involving Massachusetts Bay Community College, the New England Aquarium in Boston, and The University of the Amazon in Brazil; and to develop a science enrichment program for primary school students and teachers in the Boston Public School system. ***