CAREER: Enhancement of Minority Research Opportunities Through the Full Integration of Research and Teaching Experiences

9707644杰克逊前列腺素是一个环状脂肪酸家族，在许多生物体中都是关键生理过程的强有力的介体。前列腺素在细胞膜上通过磷脂酶A2(PLA2)和/或磷脂酶C(PLAC)以及环氧合酶(COX)的顺序作用而持续合成。PLA2/PLAC介导花生四烯酸从膜磷脂的sn-2位释放。COX将两个氧分子结合到花生四烯酸中，伴随着碳链的环化产生前列腺素。已知有两个基因编码COX，一个是结构性的COX1基因，另一个是可诱导的、早期反应的COX2基因。本研究将从COX1基因启动子和COX1mRNA水平确定调节前列腺素合成的分子机制。该项目的教育部分包括利用这一研究计划进一步为马萨诸塞湾社区学院的非传统和少数族裔学生制定生物技术计划，与马萨诸塞湾社区学院、波士顿的新英格兰水族馆和巴西的亚马逊大学共同制定相关的海洋生物技术计划，以及为波士顿公立学校系统的小学生和教师制定科学丰富计划。前列腺素是一个环状脂肪酸家族，在许多物种中都是关键生理过程的强有力的介体。本研究将从COX1基因水平确定调节前列腺素合成的分子机制。该项目的教育部分包括利用这一研究计划为马萨诸塞湾社区学院的非传统和少数族裔学生进一步开发生物技术计划；与马萨诸塞湾社区学院、波士顿的新英格兰水族馆和巴西的亚马逊大学共同开发相关的海洋生物技术计划；以及为波士顿公立学校系统的小学生和教师开发科学丰富计划。***

9707644 Jackson Prostaglandins are a family of cyclic fatty acids which are potent mediators of key physiological processes in a large variety of organisms. Prostaglandins are continuously synthesized in cell membranes by the sequential action of the key regulatory enzymes phospholipase A2 (PLA2) and/or phospholipase C (PLAC), and cyclooxygenase (COX). PLA2 /PLAC mediate the release of arachidonic acid from the sn-2 position of membrane phospholipids. COX incorporates two molecules of oxygen into arachidonic acid concomitant with the cyclization of the carbon chain to produce prostaglandin. Two genes are known to encode COX, a constitutive COX1 gene and an inducible, early-response COX2 gene. This research will determine the molecular mechanisms that regulate prostaglandin synthesis at the level of the COX1 gene promoter and COX1 mRNA. The education portion of this project includes using this research program to further develop the Biotechnology Program for non-traditional and minority students at Massachusetts Bay Community College, to develop a related Marine Biotechnology Program involving Massachusetts Bay Community College, the New England Aquarium in Boston, and The University of the Amazon in Brazil; and to develop a science enrichment program for primary school students and teachers in the Boston Public School system. %%% Prostaglandins are a family of cyclic fatty acids which are potent mediators of key physiological processes in a large variety of species. This research will determine the molecular mechanisms that regulate prostaglandin synthesis at the level of the COX1 gene. The education portion of this project includes using this research program to further develop the Biotechnology Program for non-traditional and minority students at Massachusetts Bay Community College; to develop a related Marine Biotechnology Program involving Massachusetts Bay Community College, the New England Aquarium in Boston, and The University of the Amazon in Brazil; and to develop a science enrichment program for primary school students and teachers in the Boston Public School system. ***