CAREER: Enhancement of Minority Research Opportunities Through the Full Integration of Research and Teaching Experiences

小杰克逊9707644 前列腺素是一类环状脂肪酸，是多种生物体关键生理过程的有效介质。前列腺素通过关键调节酶磷脂酶A2（PLA 2）和/或磷脂酶C（PLAC）以及环氧合酶（考克斯）的顺序作用在细胞膜中连续合成。 PLA 2/PLAC介导花生四烯酸从膜磷脂的sn-2位置的释放。 考克斯将两个氧分子结合到花生四烯酸中，伴随着碳链的环化以产生前列腺素。 已知两种基因编码考克斯，组成型COX 1基因和诱导型早期反应COX 2基因。 这项研究将确定在COX 1基因启动子和COX 1 mRNA水平上调节前列腺素合成的分子机制。 该项目的教育部分包括利用这一研究方案进一步发展马萨诸塞州海湾社区学院非传统和少数民族学生的生物技术方案，发展一个涉及马萨诸塞州海湾社区学院、波士顿新英格兰水族馆和巴西亚马逊大学的相关海洋生物技术方案;并为波士顿公立学校系统的小学生和教师制定一项科学丰富计划。 前列腺素是环状脂肪酸的一个家族，是多种物种中关键生理过程的有效介质。这项研究将确定在COX 1基因水平上调节前列腺素合成的分子机制。 该项目的教育部分包括利用这一研究方案进一步发展马萨诸塞州海湾社区学院非传统和少数民族学生的生物技术方案;发展一个涉及马萨诸塞州海湾社区学院、波士顿新英格兰水族馆和巴西亚马逊大学的相关海洋生物技术方案;并为波士顿公立学校系统的小学生和教师制定一项科学丰富计划。 ***

9707644 Jackson Prostaglandins are a family of cyclic fatty acids which are potent mediators of key physiological processes in a large variety of organisms. Prostaglandins are continuously synthesized in cell membranes by the sequential action of the key regulatory enzymes phospholipase A2 (PLA2) and/or phospholipase C (PLAC), and cyclooxygenase (COX). PLA2 /PLAC mediate the release of arachidonic acid from the sn-2 position of membrane phospholipids. COX incorporates two molecules of oxygen into arachidonic acid concomitant with the cyclization of the carbon chain to produce prostaglandin. Two genes are known to encode COX, a constitutive COX1 gene and an inducible, early-response COX2 gene. This research will determine the molecular mechanisms that regulate prostaglandin synthesis at the level of the COX1 gene promoter and COX1 mRNA. The education portion of this project includes using this research program to further develop the Biotechnology Program for non-traditional and minority students at Massachusetts Bay Community College, to develop a related Marine Biotechnology Program involving Massachusetts Bay Community College, the New England Aquarium in Boston, and The University of the Amazon in Brazil; and to develop a science enrichment program for primary school students and teachers in the Boston Public School system. %%% Prostaglandins are a family of cyclic fatty acids which are potent mediators of key physiological processes in a large variety of species. This research will determine the molecular mechanisms that regulate prostaglandin synthesis at the level of the COX1 gene. The education portion of this project includes using this research program to further develop the Biotechnology Program for non-traditional and minority students at Massachusetts Bay Community College; to develop a related Marine Biotechnology Program involving Massachusetts Bay Community College, the New England Aquarium in Boston, and The University of the Amazon in Brazil; and to develop a science enrichment program for primary school students and teachers in the Boston Public School system. ***