Genomic Database for the Flowering Plant Arabidopsis thaliana

开花植物拟南芥基因组数据库

• 批准号: 9714160
• 负责人: Joe Cherry
• 金额: $ 85.38万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9714160&HistoricalAwards=false
• 关键词: Genomic; Database; Flowering; Plant; Arabidopsis

The small flowering plant, Arabidopsis thaliana, a member of the mustard family, has become a model system for plant biology. Its unique features allow it to be applied to a wide variety of research problems, including plant physiology, the molecular genetic study of organ development, and plant- pathogen interactions. Arabidopsis has established itself in this role for several reasons: its small size; short life cycle; small genome size; low amount of repetitive DNA sequences; and the relative ease with which it is manipulated by molecular and genetic methods. The importance of Arabidopsis to plant biology is increasing with the international development of germplasm and DNA stock resource centers, genetic and physical maps and their techniques, plus expression sequence tag (EST, single pass cDNA sequences) and genomic sequencing projects. Furthermore, because flowering plants evolved recently, characterizing a gene in Arabidopsis often simplifies the isolation of a corresponding gene in another flowering plant. This project will provide an electronic database containing the genomic information for Arabidopsis thaliana including convenient and correlated access to all published and otherwise publicly available information about genes, their products, their positions on the genetic and physical maps, and their DNA sequences. Furthermore, this resource will accommodate a diverse group of users, ranging from Arabidopsis molecular biologists to other biologists whose own research problems can take advantage of work conducted using Arabidopsis. This database project will provide an information resource on the Internet using the World Wide Web using client and server software developed specifically for genomic information presentation and analysis. The primary mission of this project is to develop a scientific database using object-relational database technologies as well as to develop an appropriate interface through the WWW to the information needed by the worldwide plant molecular biological community. The major product of this project will be the creation of a database environment which will validate and store information about physical and genetic maps, DNA sequences and their features, plus cross- references to the literature and detailed primary data. Collaborations with the Arabidopsis Genome Initiative (AGI), an international group of scientists working to determine the complete DNA sequence of the Arabidopsis genome by the year 2004 have been developed to provide the plant biology community with a easy access to the maps and sequence being created around the world.

小型开花植物拟南芥， 芥菜科已成为植物模式系统 生物学其独特的功能使其能够广泛应用于 各种各样的研究问题，包括植物生理学， 器官发育的分子遗传学研究，以及植物- 病原体相互作用拟南芥已经在 这个角色有几个原因：它的体积小;寿命短 循环;小基因组大小;低重复DNA量 序列;以及它被操纵的相对容易性 通过分子和基因的方法。的重要性 拟南芥对植物生物学的影响正在增加 国际种质资源和DNA储备资源开发 中心，遗传和物理地图及其技术，加上 表达序列标签（EST，单程cDNA序列）和 基因组测序项目。此外，由于开花 植物进化最近，在拟南芥的基因特征 通常简化了相应基因的分离， 另一种开花植物。 该项目将提供一个电子数据库， 拟南芥的基因组信息包括 方便和相关的访问所有出版物， 其他公开的基因信息， 产品，它们在遗传和物理图谱上的位置， 和他们的DNA序列此外，该资源将 适应不同的用户群体，范围从 拟南芥分子生物学家和其他生物学家， 自己的研究问题可以利用工作进行 使用拟南芥。该数据库项目将提供一个 利用万维网的因特网信息资源 使用客户端和服务器软件， 基因组信息展示和分析。 这个项目的主要使命是开发一个 使用对象关系数据库的科学数据库 技术以及开发适当的接口 通过万维网向全世界提供所需的信息 植物分子生物学群落的主要产物 该项目将创建一个数据库环境 它将验证和存储有关物理和 基因图谱，DNA序列及其特征，加上交叉- 参考文献和详细的原始数据。 与拟南芥基因组计划（AGI）合作， 一个国际科学家小组致力于确定 拟南芥基因组的完整DNA序列 2004年已开发提供植物生物学 社区，可以轻松访问地图和序列， 在世界各地创造的。