I. Convergent Double Annulation Route to Highly Substituted and Oxidized Bicyclo{4.n.0}alkanes. II. Engaging Students as Participants in their Own Education.

本研究的重点是开发一种用于制备具有多官能团和多取代的双环(4.n.0)烷烃的双环策略。该方法使用串联的Michael，Dieckmann序列，将通过制备一些有趣的多萜化合物来展示其实用性。教育活动的重点是课程开发，其特点是使用基于网络的互动作业和论文作业。凭借这一教师早期发展(职业)奖，有机和高分子化学项目正在支持肯塔基大学化学系罗伯特·B·格罗斯曼博士的研究和教育活动。格罗斯曼教授将把他的研究重点放在开发可用于制备具有有趣生物特性的有机化合物的合成方法上。该奖项的教育部分将强调本科生有机化学的课程开发。

The focus of this research is the development of a double annulation strategy for the preparation of bicyclo(4.n.0)alkanes with multiple functionality and substitution. The utility of the method, which employs a tandem Michael, Dieckmann sequence, will be showcased by the preparation of a number of interesting polyterpenoids. The focus of the educational activities is on course development featuring the use of web-based, interactive homework and essay assignments. With this Faculty Early Development (CAREER) award, the Organic and Macromolecular Chemistry Program is supporting the research and educational activities of Dr. Robert B. Grossman of the Department of Chemistry at the University of Kentucky. Professor Grossman will focus his research efforts on developing synthetic methodology useful in the preparation of organic compounds having interesting biological properties. The educational component of the award will stress course development in undergraduate organic chemistry.