Postdoctoral Research Fellowship in Biosciences Related to the Environment for FY 1997

香农·斯塔尔（Shannon Stahl）：本行动资助了1997年美国国家科学基金会与环境有关的生物科学博士后研究奖学金。该奖学金为研究员提供了获得博士学位以外的额外科学培训的机会，并在美国国家科学基金会生物科学理事会支持的任何生物学领域中，在分子、细胞、有机体、种群、群落和/或生态系统层面上，对生物与其环境之间相互作用的基本机制进行创新和富有想象力的研究。每个奖学金支持在赞助实验室进行的研究和培训计划。这项奖学金的研究和培训计划的题目是“甲烷单加氧酶的研究，这是一种对石油泄漏清理和温室气体排放很重要的酶。”甲烷单加氧酶（MMO）催化甲烷的好氧氧化生成甲醇，在从全球变暖到生物修复等环境问题上具有重要意义。本研究利用动力学同位素效应研究和定点诱变等多种方法探讨了MMO的双氧活化和底物氧化机制。

Abstract DBI 9750196 Shannon Stahl This action funds an NSF Postdoctoral Research Fellowship in Biosciences Related to the Environment for 1997. This fellowship provides an opportunity for the Fellow to gain additional scientific training beyond the doctoral degree and to pursue innovative and imaginative into the fundamental mechanisms underlying the interactions between organisms and their environment at the molecular, cellular, organismal, population, community and/or ecosystem level in any area of biology supported by the Directorate for Biological Sciences of the National Science Foundation. Each fellowship supports a research and training plan to be carried out in a sponsoring laboratory. The research and training plan for this fellowship is entitled "Studies of methane monooxygenase, an enzyme important for oil spill cleanup and greenhouse gas depletion." Methane monooxygenase (MMO) catalyzes the aerobic oxidation of methane to methanol and has important implications for environmental issues ranging from global warming to bioremediation. This research examines the mechanism of dioxygen activation and substrate oxidation by MMO using various methods ranging from kinetic isotope effect studies to site-directed mutagenesis.