SBIR Phase I: Complete Software System for 3D Surface Modeling of Anatomy from 2D Sections

这个小企业创新研究第一阶段项目来自可见的生产有限责任公司。旨在开发一个软件系统的初始版本，该软件系统可以从2D截面数据（如CT、MRI和Visible Human Project图像）有效地创建解剖结构的3D多边形网格表面模型。 软件系统将包括改进和整合以下现有模块：1）半自动跟踪模块，该模块利用神经网络对二维切片图像上的解剖结构周边进行用户辅助和半自动跟踪; 2）基于三维模型的配准模块，该模块根据需要转换相邻切片图像和单个结构，以确保正确对齐和配准; 3）自动连接三角剖分模块，一种改进的三角剖分软件，它从跟踪的2D周长创建3D多边形表面，几乎没有用户干预;和4）后处理系统，一种改进的软件，用于编辑，抽取和重塑多边形网格表面，以定制模型。 第一阶段将集中开发和测试半自动追踪模块，因为这是Visible Productions目前系统中开发最少的部分。 将提出基于模型的登记系统的概念和计划。 Visible Productions现有的三角测量和后处理模块将得到改进，项目团队将开始与其他模块的集成工作。 解剖结构的3D多边形网格模型有非常大的市场，但可用于创建这些模型的工具非常有限。 这些模型的用户包括研究人员、教育工作者、医疗专业人员、诊断专家、多媒体出版商、模拟设计专家以及娱乐和游戏行业的工程师。 Visible Productions的软件将允许这些不同的群体以合理的价格有效地创建自己的模型。 此外，该系统将允许以比目前更快的速度为客户创建定制模型。

This Small Business Innovation Research Phase I project from Visible Productions L.L.C. seeks to develop the initial version of a software system that can efficiently create 3D polygonal mesh surface models of anatomical structures from 2D section data such as CT, MRI and Visible Human Project images. The software systems will consist of refining and integrating the following existing modules: 1) Semi-automated tracing module, which utilizes neural networks to perform user-assisted and semi-automated tracing of the perimeters of anatomical structures on 2D section images; 2) 3D model-based registration module which transforms adjacent section images and individual structures as necessary to ensure proper alignment and registration; 3) Automatic connectivity triangulation module, an improved triangulation software which creates 3D polygon surfaces from the traced 2D perimeters with little user intervention; and 4) Post-processing system, an improved software for editing, decimating, and reshaping polygonal mesh surfaces for customizing the models. The Phase I will concentrate on development and testing of the semi-automated tracing module since this is the least developed component in Visible Productions' current system. A concept and plan for a model-based registration system will be generated. Visible Productions' existing triangulation and post-processing modules will be improved and the project team will begin the integration effort with other modules. There is a very large market for 3D polygonal mesh models of anatomical structures, but the tools available to create these models are very limited. The users of such models include researchers, educators, medical professionals, diagnosticians, multimedia publishers, simulation design specialists, and entertainment and gaming industry engineers. Visible Productions' software would allow these diverse groups to efficiently create their own models at a reasonable price. Also, the system will allow the creation of custom models for customers at a much faster rate than is currently possible.