STTR Phase I: Raman Spectroscopy for Control of Ethylene Oxide and Other Atmospheric Contaminants

STTR 第一阶段：用于控制环氧乙烷和其他大气污染物的拉曼光谱

• 批准号: 9810572
• 负责人: Robert Benner
• 金额: $ 10万
• 依托单位: Process Instruments Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9810572&HistoricalAwards=false
• 关键词: STTR; Phase; Raman; Spectroscopy; Control

9810572Benner This Phase I Small Business Technology Transfer (STTR) project will demonstrate that a full-spectrum Raman analyzer prototype with no moving parts that incorporates a small, novel Raman optical-fiber based enhancement cell can rapidly measure Ethylene Oxide (EtO) and other gases down to low ppm levels. Raman's high degree of specificity minimizes signal cross-talk in complex multicomponent systems. The spectra have narrow peaks which can be observed easily even in the presence of moisture. In order to make gas-phase Raman analysis affordable and practical we will use an off-the- shelf laser diode array as a light source. A proprietary external-cavity configuration will narrow the linewidth to around 10 cm-1. A simple, fiber-optic loop will enhance the circulating laser energy by approximately 10 X to obtain sufficiently high laser energy for gas-phase detection at low concentrations. The Raman signal will be collected with a rugged, optically fast (f/1.4) volume- holographic spectrograph, and the full spectrum will be detected using a sensitive TE-cooled CCD array detector. This approach offers a simple, reliable instrument with no moving parts, for reduced maintenance and good stability. EtO is a colorless gas commonly used for sterilization of medical products that are temperature sensitive, which has been demonstrated to be a respiratory, skin, and eye irritant even at low concentrations (50 ppm). In addition, long-term exposure to EtO presents mutagenic, reproductive, and carcinogenic complications to humans. Below 700 ppm the odor of EtO cannot be detected. A gas sensor is needed to rapidly monitor EtO. The proposed work will demonstrate the ease of use and breadth of application of Raman instrumentation compared to conventional IR, mass spectroscopy, or GC methodologies in a large U.S. market for industrial process analyzers.

小行星9810572 该第一阶段小企业技术转让（STTR）项目将证明，一个没有移动部件的全光谱拉曼分析仪原型，包括一个小型的、新型的基于拉曼光纤的增强单元，可以快速测量环氧乙烷（EtO）和其他气体，低至ppm水平。拉曼的高度特异性使复杂多组分系统中的信号串扰最小化。光谱具有窄峰，即使在存在水分的情况下也可以容易地观察到。为了使气相拉曼分析负担得起和实用，我们将使用现成的激光二极管阵列作为光源。专有的外腔配置将线宽缩小到10 cm-1左右。一个简单的光纤回路将使循环激光能量提高约10倍，以获得足够高的激光能量，用于低浓度下的气相检测。拉曼信号将用坚固耐用的光学快速（f/1.4）体积全息光谱仪收集，并且全光谱将使用灵敏的TE冷却CCD阵列检测器检测。这种方法提供了一种简单、可靠的仪器，没有移动部件，减少了维护和良好的稳定性。环氧乙烷是一种无色气体，常用于对温度敏感的医疗产品的灭菌，已证明即使在低浓度（50 ppm）下也会对呼吸道、皮肤和眼睛产生刺激。此外，长期暴露于EtO会对人类造成致突变、生殖和致癌并发症。低于700 ppm时，无法检测到EtO的气味。需要气体传感器来快速监测EtO。 拟议的工作将证明拉曼仪器的易用性和广泛的应用相比，传统的红外光谱，质谱，或气相色谱方法在美国的一个大市场的工业过程分析仪。