Dynamics of intermediate filament self-assembly (B07)

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Intermediate filaments in the cytoskeleton of eukaryotes are a major contributor to the mechanical properties of cells. The hierarchical build-up of the filaments from subunits and the formation of networks will be studied. We will combine nano- and micro-imaging and scattering methods with microfluidic techniques. In particular, our aim is to understand the influence of mono- or multivalent ions on the assembly and the resulting mechanical properties.