Laser Welding of Tissue: Modeling and Experiments

组织激光焊接：建模和实验

• 批准号: 9813959
• 负责人: Joseph Walsh
• 金额: $ 25.85万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-10-01 至 2002-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9813959&HistoricalAwards=false
• 关键词: Laser; Welding; Tissue; Modeling; Experiments

9813959 Walsh The objective of this research is to add to the scientific basis of laser welding by using absorptive dyes through a sequence of theoretical and experimental studies. These studies will involve optimization of a nmber of laser, dye, cooling, and tissue parameters. The main goals of this research are to: (1) develop a Monte Carlo based model of optical transport with a computational heat transfer model in order to explore the full range of welding parameters that can be varied and guide the proposed experimental work, (2) conduct a series of experiments that more fully explores the range of welding parameters available, (3) develop an interactive cooling system to increase weld strength, decrease surface thermal damage, decrease operative time, and potentially decrease operative and post-operative pain, (4) explore several vital dyes of use in tissue engineering, (5) understand the advantages and disadvantages of several dye delivery systems, and (6) explore the welding of tissues other than skin.

9813959 Walsh这项研究的目的是通过一系列的理论和实验研究，利用吸收性染料来增加激光焊接的科学基础。这些研究将涉及许多激光、染料、冷却和组织参数的优化。本研究的主要目标是：(1)利用计算传热模型建立基于蒙特卡罗的光传输模型，以探索可变化的全范围焊接参数，并指导提出的实验工作；(2)进行一系列实验，更充分地探索可用的焊接参数范围；(3)开发交互冷却系统，以提高焊接强度，减少表面热损伤，缩短操作时间；以及潜在地减少手术和术后疼痛，(4)探索组织工程中使用的几种重要染料，(5)了解几种染料输送系统的优缺点，(6)探索皮肤以外组织的焊接。