Development of a Laboratory Instrument for In-situ Measurement, Characterization, and Optimization of Batch Reactions

开发用于批量反应原位测量、表征和优化的实验室仪器

• 批准号: 9815569
• 负责人: Arlene Garrison
• 金额: $ 10万
• 依托单位: University of Tennessee Knoxville
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9815569&HistoricalAwards=false
• 关键词: Development; Laboratory; Instrument; situ; Measurement

9815569GarrisonThis project is carried out as a part of the NSF Research Centers - Small Firms Collaborative R&D initiative, under the leadership of the Center for Measurement and Control Engineering, an IUCRC established by the National Science Foundation. Headquartered at the University of Tennessee, the Center has several collaborating institutions, including East Carolina University. In this project, a prototype instrument will be developed and used that integrated self-modeling curve resolution (SMCR) software with fiber-optic UV/visible spectrograph an and an automated four station mini-reactor/calorimeter into one package. The prototype instrument for making lab-scale and pilot-scale measurements of synthetic organic reactions. Commercial transmission and reflectance probes will be used for in-situ measurements. A small business partner, H&A Scientific, will design and produce the prototype instrument by integrating, OEM components with SMCR software produced with technology transfer support from East Carolina University (ECU). One of the main goals of this project is to develop a user interface that reduces the complexity of the SMCR problem as perceived by the instrument user. A small development team at H&A Scientific will undertake this aspect of the project. A second prototype instrument will be assembled with funds provided by Glaxo Wellcome, Inc (GWI) to H&A Scientific. The two prototype instruments will serve as test beds for user interface design and ease of use at ECU, and by non-chemometricians and research scientists at GWI. Both business partners (H&A Scientific and GWI) are expected to make significant contributions in this area.

9815569 garrison本项目是国家自然科学基金会研究中心-小型企业协同研发计划的一部分，由国家自然科学基金会建立的IUCRC测控工程中心领导。该中心总部设在田纳西大学，有几个合作机构，包括东卡罗莱纳大学。在这个项目中，将开发和使用一个原型仪器，该仪器将自建模曲线分辨率（SMCR）软件与光纤紫外/可见光谱仪和一个自动化的四站微型反应器/量热计集成在一个包中。用于合成有机反应的实验室规模和中试规模测量的原型仪器。商业传输和反射探头将用于现场测量。小型商业合作伙伴H&amp；A Scientific将通过集成OEM组件和SMCR软件来设计和生产原型仪器，SMCR软件是在东卡罗莱纳大学（ECU）的技术转让支持下生产的。该项目的主要目标之一是开发一个用户界面，以减少仪器用户所感知的SMCR问题的复杂性。H&amp；A Scientific的一个小型开发团队将承担该项目的这方面工作。第二个原型仪器将由葛兰素威康公司（GWI）提供给H&amp；A Scientific公司的资金组装。这两个原型仪器将作为ECU的用户界面设计和易用性的测试平台，并由GWI的非化学计量学家和研究科学家使用。两个商业伙伴（H&amp；A Scientific和GWI）都有望在这一领域做出重大贡献。