Upgrade and Installation of Triple Quadrupole Mass Spectrometer for Research in Chemistry of Radical-Cations and Undergraduate Instruction in Mass Spectrometric Techniques

化学研究仪器和设施(CRIF)/初级教师计划颁发的这一奖项将允许主要是本科生的雷吉斯大学化学系升级和安装三重四极质谱仪。史蒂芬·F·卡蒂埃是一名初级教员，他将利用这台仪器进行自由基阳离子化学领域的基础研究，并将现代质谱学技术引入本科化学课程。他的团队将使用电喷雾电离-质谱仪研究重氮烷和卡宾自由基阳离子体系。学生研究助理将学习电喷雾电离的基本原理--三重四极杆质谱仪，并参与数据采集和分析。该部门还将把质谱仪纳入高级实验室课程，在课程中增加几个新的实验，包括多肽测序、离子过渡金属络合物、富勒烯及其衍生物、有机电化学和痕量化学检测的研究。质谱仪(MS)是一种用于探测大量有机、生物有机和有机金属分子的内部结构细节和获得其分子组成的技术。电喷雾技术的加入将MS的范围扩展到蛋白质和核酸的相对分子质量，远远超过了任何其他技术。电喷雾电离与高分辨率相结合的使用为化合物的表征提供了最强大的工具之一。在质谱学中获得这种能力对于开展许多化学领域的前沿研究是至关重要的。

This award from the Chemistry Research Instrumentation and Facilities (CRIF)/Junior Faculty Program will allow the Department of Chemistry at Regis University, a primarily undergraduate institution, to upgrade and install a triple quadrupole mass spectrometer. Stephen F. Cartier, a junior faculty member, will use this instrument to pursue fundamental research in the field of radical cation chemistry and introduce modern mass spectrometric techniques to the undergraduate chemistry curriculum. His group will investigate diazoalkane and carbene radical cation systems using electrospray ionization-mass spectrometry. Student research assistants will learn the fundamentals of electrospray ionization-triple quadrupole mass spectrometry and participate in data acquisition and analysis. The department will also incorporate the mass spectrometer into upper level laboratory courses by adding several new experiments to the curriculum, including investigations of peptide sequencing, ionic transition-metal complexes, fullerenes and their derivatives, organic electrochemistry, and trace chemical detection. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to protein and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for carrying out frontier research in many fields of chemistry.