Upgrade and Installation of Triple Quadrupole Mass Spectrometer for Research in Chemistry of Radical-Cations and Undergraduate Instruction in Mass Spectrometric Techniques

来自化学研究仪器和设施（CRIF）/初级教师计划的这一奖项将允许瑞吉斯大学化学系（主要是本科院校）升级和安装三重四极杆质谱仪。 Stephen F.卡地亚，一个初级教师，将使用这种仪器进行基础研究，在自由基阳离子化学领域，并介绍现代质谱技术的本科化学课程。 他的小组将使用电喷雾电离质谱法研究重氮烷和卡宾自由基阳离子系统。 学生研究助理将学习电喷雾电离-三重四极杆质谱的基础知识，并参与数据采集和分析。 该部门还将通过增加几个新的实验课程，包括肽测序，离子过渡金属络合物，富勒烯及其衍生物，有机电化学和痕量化学检测的调查，将质谱仪纳入高级实验室课程。 质谱（MS）是一种用于探测紧密结构细节并获得大量有机、生物有机和有机金属分子的分子组成的技术。电喷雾技术的加入将质谱的范围扩展到蛋白质和核酸分子量，远远超过任何其他技术。电喷雾离子化与高分辨率结合使用为化合物的表征提供了最强大的工具之一。在质谱分析中获得这种能力对于在许多化学领域进行前沿研究至关重要。

This award from the Chemistry Research Instrumentation and Facilities (CRIF)/Junior Faculty Program will allow the Department of Chemistry at Regis University, a primarily undergraduate institution, to upgrade and install a triple quadrupole mass spectrometer. Stephen F. Cartier, a junior faculty member, will use this instrument to pursue fundamental research in the field of radical cation chemistry and introduce modern mass spectrometric techniques to the undergraduate chemistry curriculum. His group will investigate diazoalkane and carbene radical cation systems using electrospray ionization-mass spectrometry. Student research assistants will learn the fundamentals of electrospray ionization-triple quadrupole mass spectrometry and participate in data acquisition and analysis. The department will also incorporate the mass spectrometer into upper level laboratory courses by adding several new experiments to the curriculum, including investigations of peptide sequencing, ionic transition-metal complexes, fullerenes and their derivatives, organic electrochemistry, and trace chemical detection. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to protein and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for carrying out frontier research in many fields of chemistry.