Computational Modeling and Measurement of Electro-Osmosis

电渗透的计算建模和测量

• 批准号: 9871994
• 负责人: William Brownell
• 金额: $ 64.75万
• 依托单位: Baylor College of Medicine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 2002-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9871994&HistoricalAwards=false
• 关键词: Computational; Modeling; Measurement; Electro; Osmosis

9871994BrownellThis is theoretical and experimental research on electro-osmosis in membranes in the outer hair cell lateral wall in the mammalian inner ear. The investigators claim that the outer hair cell can be regarded as a naturally occurring microelectromechanical (MEM) system, in which voltages induce fluid transport through the 33 nm wide extracisternal space. A set of differential equations has been developed to model the coupling between electrostatic potentials and fluid flow in the system. They will use this model to predict the effects of applied voltages on fluid transport under a variety of conditions. These predictions will be tested experimentally through optical measurements of the displacement of fluorescent molecules within the extracisternal space. The goal is to derive general principles about the interaction between voltages and fluid flow in nanostructures, which can be exploited in artificial MEM systems.***

9871994 Brownell这是对哺乳动物内耳外毛细胞侧壁膜中电渗的理论和实验研究。 研究人员声称，外毛细胞可以被视为一种自然发生的微机电（MEM）系统，其中电压诱导流体通过33 nm宽的脑池外空间运输。 一组微分方程已开发的静电势和流体流动之间的耦合模型的系统。 他们将使用这个模型来预测在各种条件下施加电压对流体传输的影响。 这些预测将通过对脑池外空间内荧光分子位移的光学测量进行实验测试。 目标是推导出关于纳米结构中电压和流体流动之间相互作用的一般原理，这些原理可以在人工MEM系统中利用。