The role of Whirly proteins in transcriptional control of leaf senescence and cell death processes in Arabidopsis thaliana

Whirly 蛋白在拟南芥叶片衰老和细胞死亡过程转录控制中的作用

• 批准号: 131502578
• 负责人: Professorin Dr. Ying Miao
• 金额: --
• 依托单位: Fuzhou University
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/131502578?language=en
• 关键词: role; Whirly; proteins; transcriptional; control

Senescence is the last phase of leaf development finally leading to death of the tissue. This phase of development is characterized by remobilization of nutrients and in crop plants limits yield when it is induced prematurely by stress. Its complex regulation has been mainly studied in Arabidopsis thaliana. It has been shown that transcription factors of the WRKY and NAC families have prominent roles in controlling the process. Our research has demonstrated that Whirly proteins constitute another family of transcription factors controlling senescence as well as cell death processes during pathogen infection whereby Whirly1 acts upstream of WRKY transcription factors. Moreover we showed that Whirly1 is an exceptional transcription factor with a dual location in the nucleus and plastids. The major goal of the project is to elucidate the molecular mechanism of the upstream regulation of WRKY transcription factors by Whirly1. Besides epigenetic factors, also the significance of Whirly1 interaction partners will be investigated.

衰老是叶子发育的最后阶段，最终导致组织死亡。这一发育阶段的特点是营养物质的再利用，并且当作物因胁迫而过早诱导产量时，产量就会受到限制。其复杂的调控主要在拟南芥中进行研究。研究表明，WRKY 和 NAC 家族的转录因子在控制该过程中发挥着重要作用。我们的研究表明，Whirly 蛋白构成了另一个转录因子家族，在病原体感染期间控制衰老和细胞死亡过程，其中 Whirly1 作用于 WRKY 转录因子的上游。此外，我们发现 Whirly1 是一种特殊的转录因子，在细胞核和质体中具有双重位置。该项目的主要目标是阐明Whirly1对WRKY转录因子上游调控的分子机制。除了表观遗传因素外，还将研究 Whirly1 相互作用伙伴的重要性。