CAREER: Tripodal Aryloxide Ligands: From Molecular Receptors to Organometallic Catalysis

这个无机化学、生物无机化学和金属有机化学项目的职业奖项支持佛罗里达大学化学系的迈克尔·斯科特博士对结构定义的配体的研究和教育。合成了一类新的具有碗状结构的三脚架芳氧基配体。配体可以通过化学修饰来调节，以选择性地结合各种金属离子或改变它们的反应性。一些配体具有足够的刚性，可以用来组装含有金属离子的超分子结构。配体有三个结合位点，因此可以将一个以上的金属中心与配体主干结合，但寡聚作用受到抑制。含有铝的化合物将被制备成强大的催化剂，用于烷基化、环加成和许多其他化学反应。参与该项目的本科生将学习分子识别和催化，以及合成和表征方面的技能。这一职业奖的教育部分将侧重于为生物化学学生开发一门无机生物化学课程，并在该系提供一门本科生研究课程。

This CAREER award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research and education on structurally defined ligands by Dr. Michael Scott of the Chemistry Department, University of Florida. A new class of tripodal aryloxide ligands with a preorganized bowl-like shape will be synthesized. The ligands can be adjusted by chemical modification to selectively bind various metal ions or to alter their reactivity. Some of the ligands are sufficiently rigid that they can be used in the assembly of supramolecular structures containing metal ions. The ligands have three binding sites and so binding of more than one metal center to the ligand backbone is possible, yet oligomerization is inhibited. Compounds containing aluminum will be prepared which will be useful as robust catalysts for alkylations, cycloadditions and many other chemical reactions. Undergraduate students involved in the project will learn about molecular recognition and catalysis, in addition to skills in synthesis and characterization. The educational component of this CAREER Award will focus on developing a course in inorganic biochemistry for biochemistry students and on offering an undergraduate research course in the department.