CAREER: Tripodal Aryloxide Ligands: From Molecular Receptors to Organometallic Catalysis

这个职业奖在无机，生物无机和有机化学计划支持的研究和教育结构定义的配体博士迈克尔斯科特的化学系，佛罗里达大学。 合成了一类新的具有预组装碗状结构的三脚架型芳氧化合物配体。 配体可以通过化学修饰来调节，以选择性地结合各种金属离子或改变它们的反应性。 一些配体具有足够的刚性，使得它们可以用于组装含有金属离子的超分子结构。 配体具有三个结合位点，因此可以将一个以上的金属中心结合到配体骨架上，但寡聚化被抑制。 将制备含铝化合物，其将用作烷基化、环加成和许多其它化学反应的稳健催化剂。 参与该项目的本科生将学习分子识别和催化，以及合成和表征技能。 该职业奖的教育部分将侧重于为生物化学学生开发无机生物化学课程，并在系内提供本科研究课程。

This CAREER award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research and education on structurally defined ligands by Dr. Michael Scott of the Chemistry Department, University of Florida. A new class of tripodal aryloxide ligands with a preorganized bowl-like shape will be synthesized. The ligands can be adjusted by chemical modification to selectively bind various metal ions or to alter their reactivity. Some of the ligands are sufficiently rigid that they can be used in the assembly of supramolecular structures containing metal ions. The ligands have three binding sites and so binding of more than one metal center to the ligand backbone is possible, yet oligomerization is inhibited. Compounds containing aluminum will be prepared which will be useful as robust catalysts for alkylations, cycloadditions and many other chemical reactions. Undergraduate students involved in the project will learn about molecular recognition and catalysis, in addition to skills in synthesis and characterization. The educational component of this CAREER Award will focus on developing a course in inorganic biochemistry for biochemistry students and on offering an undergraduate research course in the department.