International Research Fellow Awards: Meiotic Maturation and Cryopreservation of Starfish Oocytes

国际研究员奖：海星卵母细胞减数分裂成熟和冷冻保存

• 批准号: 9902703
• 负责人: Kirsten Sadler
• 金额: $ 3.51万
• 依托单位: Fellowships
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9902703&HistoricalAwards=false
• 关键词: International; Research; Fellow; Awards; Meiotic

9902703SadlerThe International Research Fellow Awards Program enables U.S. scientists and engineers to conduct three to twentyfour months of research abroad. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad.This award will provide support for a twelve-month postdoctoral research visit by Dr. Kirsten C. Sadler to work with Dr. Asli Tolun at Bosphorus University in Istanbul, Turkey.The goal of this research is to identify components of the signaling pathway and the motogen receptor in starfish oocytes. This is important because neither the hormone receptor nor the early signal transduction pathways have identified in any oocyte. Starfish oocytes have long been used as a model for studying the cell cycle and meiotic maturation. The oocytes are stored in the ovary arrested in the first meiotic cell cycle and upon stimulation by their natural mitogen, they re-enter the cell cycle and develop fertilization competency. Conversion of an immature oocyte to a fertilizable egg is termed oocyte maturation.The university is located on the Bosphorus and in close proximity to the Sea of Marmara, which is filled with starfish. In addition, the geographic position of Turkey allows access to the Black Sea, the Aegean and the Mediterranean. The environments of each are unique and support different species of starfish with different reproductive cycles, providing a unique opportunity to obtain material for comparative studies. In addition to working with researchers at Bosphorus University, Dr. Sadler will be able to form collaborations with other researchers in Europe, such as Dr. Christain Sardet at Villefranche, France.***

9902703萨德勒国际研究员奖励计划使美国科学家和工程师能够在国外进行三到二十四个月的研究。 该项目的奖项为联合研究以及使用国外独特或互补的设施、专业知识和实验条件提供了机会。该奖项将为 Kirsten C. Sadler 博士与土耳其伊斯坦布尔博斯普鲁斯大学的 Asli Tolun 博士进行为期 12 个月的博士后研究访问提供支持。这项研究的目标是鉴定海星信号通路和运动原受体的组成部分 卵母细胞。 这很重要，因为在任何卵母细胞中都没有发现激素受体和早期信号转导途径。 海星卵母细胞长期以来被用作研究细胞周期和减数分裂成熟的模型。 卵母细胞储存在卵巢中，在第一个减数分裂细胞周期中停滞，在天然有丝分裂原的刺激下，它们重新进入细胞周期并发展受精能力。 未成熟卵母细胞向受精卵的转化称为卵母细胞成熟。该大学位于博斯普鲁斯海峡，靠近充满海星的马尔马拉海。 此外，土耳其地理位置优越，可通往黑海、爱琴海和地中海。 每个海星的环境都是独特的，支持具有不同繁殖周期的不同种类的海星，为获取比较研究材料提供了独特的机会。 除了与博斯普鲁斯大学的研究人员合作外，Sadler 博士还将能够与欧洲的其他研究人员建立合作，例如法国自由城的 Christin Sardet 博士。***