REU Supplement: New Chiral Kemp's Acid Derivatives; Synthesis and Resolution of Potential Artificial Enzymes

9911958Baldwin本提案支持密歇根州Spring Arbor学院化学系Bruce Baldwin博士和日本埼玉大学工程学院应用化学系Takuji Hirose博士之间的美日合作研究。鲍德温博士将在埼玉大学获得为期三个月的资助，以开发新的化学传感器或手性分子识别剂。这些新药物将是东道主科学家广濑拓二博士和PI先前在日本完成的工作的自然延伸。传统的和酶的方法将被用来使目标分子立体选择性。传统方法将产生目标手性分子的外消旋混合物，通过手性柱技术分离或作为二对映体盐。酶促法利用了美国PI在酶促有机化学方面的经验，利用天然酶制造人工酶。化学识别片段的分子工程对于开发具有独特性能的新材料、传感器等分子器件以及立体控制合成和分离系统至关重要。美国和日本的化学家和工业界都对这些体系非常感兴趣，因此这些研究将有利于对两国都很重要的化学知识。预计这些实验室之间的合作将促进未来的合作，促进科学资源和思想的国际交流。

9911958BaldwinThis proposal supports U.S.-Japan collaborative research between Dr. Bruce Baldwin of the Department of Chemistry, Spring Arbor College, Spring Arbor, MI and Dr. Takuji Hirose, Department of Applied Chemistry, Faculty of Engineering, Saitama University, Saitama, Japan. Dr. Baldwin will be supported for three months at Saitama University in order to develop new chemical sensors or recognition agents for chiral molecules. These new agents would be the natural extension of work previously completed in Japan by the host scientist, Dr. Takuji Hirose, and the PI.Conventional and enzymatic methods will be used to make the target molecules stereoselectively. The conventional approach will produce a racemic mixture of the target chiral molecules, separated by chiral column technology or as distereomeric salts. The enzymatic method capitalizes on the American PI's experience with enzymatically promoted organic chemistry, making an artificial enzyme using a natural enzyme.Molecular engineering of chemical recognition moieties is crucial for developing new materials having unique properties, molecular devices such as sensors, and stereocontrolled synthesis and separation systems. Chemists and industries in both the United States and Japan are intensely interested in these systems, so these studies will benefit the chemical knowledge of mutual importance to both countries. It is expected that the cooperation between these laboratories should foster future collaborations and promote international exchange of scientific resources and ideas.