Postdoctoral Research Fellowship in Biological Informatics for FY-1999

本行动资助1999年美国国家科学基金会生物信息学博士后研究奖学金。研究和培训计划是在生物物理学领域，题为“用于高通量核磁共振结构测定的蛋白质核磁共振光谱自动分析：人类蛋白质组计划的新技术”。高通量蛋白质结构测定（HTPSD）将成为人类蛋白质组计划的一项关键技术。对于核磁共振HTPSD来说，谱共振分配的自动化是必不可少的。AutoAssign是一个基于约束的专家系统，可以使用9个特定的NMR实验自动确定骨干共振分配。该项目支持AutoAssign的进一步开发，以使用多种核磁共振数据健壮地确定“完整”的共振分配。

This action funds an NSF Research Postdoctoral Research Fellowship in Biological Informatics for 1999.The research and training plan is in the area of biophysics and is entitled "Automatic analysis of protein NMR spectra for high-throughput NMR structure determination: a new technique for the Human Proteome Project." High-throughput protein structure determination (HTPSD) will be a key technique in the Human Proteome Project. For NMR HTPSD, automation of spectral resonance assignment is essential. AutoAssign is a constraint-based expert system that automatically determines backbone resonance assignments using nine specific NMR experiments. This project supports further development of AutoAssign to robustly determine "complete" resonance assignments using many kinds of NMR data.