Neural and Chemosensory Control of Behavior

行为的神经和化学感应控制

• 批准号: 9974530
• 负责人: David Edwards
• 金额: $ 5.49万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9974530&HistoricalAwards=false
• 关键词: Neural; Chemosensory; Control; Behavior

Reproductive behaviors are essential for the survival of all mammalian species. Testicular horomones are required for reproduction, and hormones activate mating in males by actions that increase the sexual responsiveness of males and females. The proposed research has to do with the neural pathways through which the olfactory systems and populations of hormones-sensitive neurons in the brain regulate reproductive behavior in the male rat. Immunocytochemical techniques will be used to identify horomone-sensitive neurons and neurons that are active during mating. Special attention ill be given to a brain region that includes the zona incerta and central tegmental field. Restoration of mating in castrate males by incerta/tegmental hormone implants can show the importance of the region for the hormonal regulation of mating. Studying the effect of small lesions to this region can help identify neuronal cell essential for copulation, and provide a foundation for tract-tracing designed to reveal the projecting systems through which horomones exert their effects on reproductive behavior. Because erection is the cardinal sign of arousal in males of all mammalian species, the studies should have relevance for understanding how male arousal and reproductive behavior are represented in the organization of the brain in rats and even more complexly evolved mammalian species.

生殖行为对所有哺乳动物物种的生存至关重要。 生殖需要睾丸激素，激素通过增加雄性和雌性的性反应来激活雄性的交配。 这项拟议中的研究与嗅觉系统和大脑中对气味敏感的神经元群体调节雄性大鼠生殖行为的神经通路有关。 免疫细胞化学技术将被用来确定激素敏感的神经元和交配过程中活跃的神经元。 特别注意将给予一个大脑区域，其中包括小脑角和中央被盖领域。 恢复交配的去势男性incerta/被盖激素植入物可以显示该地区的重要性，为激素调节交配。 研究该区域的小损伤的影响可以帮助识别交配所必需的神经细胞，并为旨在揭示激素对生殖行为发挥作用的投射系统的束追踪提供基础。 因为勃起是所有哺乳动物物种雄性唤醒的主要标志，这些研究应该与理解雄性唤醒和生殖行为如何在大鼠甚至更复杂进化的哺乳动物物种的大脑组织中表现有关。