Genetic Stocks of the Axolotl, Ambystoma Mexicanum

墨西哥蝾螈的遗传种群

• 批准号: 9982208
• 负责人: George Malacinski
• 金额: $ 48.66万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-15 至 2003-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9982208&HistoricalAwards=false
• 关键词: Genetic; Stocks; Axolotl; Ambystoma; Mexicanum

AbstractThis award provides renewed funding for the Indiana University Axolotl Colony, a self-sustaining, breeding colony of the Mexican axolotl (Ambystoma mexicanum). The Colony is a genetic stock center dedicated to the supply of genetically well-characterized axolotl embryos, larvae, and adults to laboratories throughout the United States and abroad. The IU Colony currently provides 50,000 embryonic, larval, juvenile and adult animals to researchers and educators each year.The axolotl, a neotenic salamander, is a non-mammalian model system with a number of features that are advantageous in experimental studies of vertebrate developmental biology, neuroscience, and immunology. These include large oocytes that display lampbrush chromosomes; large, polyspermic eggs that are suitable for nuclear transplantation and that can be easily manipulated to obtain haploids or polyploid embryos; large, accessible embryos that tolerate microsurgery well; large individual nerve cells; and the ability to regenerate limbs and organs.

摘要该奖项为印第安纳州大学蝾螈种群提供了新的资金，该种群是墨西哥蝾螈（Ambystoma mexicanum）的一个自我维持的繁殖种群。殖民地是一个遗传储备中心，致力于向美国和国外的实验室提供遗传特征良好的蝾螈胚胎，幼虫和成虫。 目前，IU每年为研究人员和教育工作者提供50，000只胚胎、幼虫、幼年和成年动物。美西螈是一种幼生期蝾螈，是一种非哺乳动物模型系统，具有许多特征，有利于脊椎动物发育生物学、神经科学和免疫学的实验研究。 这些包括显示灯刷染色体的大卵母细胞;适合核移植并且可以容易地操作以获得单倍体或多倍体胚胎的大的多精卵;耐受显微手术的大的可接近的胚胎;大的个体神经细胞;以及再生肢体和器官的能力。