Genetic Stocks of the Axolotl, Ambystoma Mexicanum

该奖项为印第安纳大学Axolotl群体提供了新的资金，该群体是墨西哥Axolotl(Ambystoma Micianum)的一个自我维持的繁殖群体。殖民地是一个基因储备中心，致力于向美国和国外的实验室提供具有良好遗传特征的axolotl胚胎、幼虫和成虫。Iu Colony目前每年为研究人员和教育工作者提供50,000只胚胎、幼体、幼体和成年动物。Axolotl是一种新生蜥蜴，是一种非哺乳动物模型系统，具有许多特征，有利于脊椎动物发育生物学、神经科学和免疫学的实验研究。这些问题包括：显示灯刷染色体的大型卵母细胞；适合进行核移植且易于操纵以获得单倍体或多倍体胚胎的大型多精卵；能很好地耐受显微手术的大型胚胎；大型单个神经细胞；以及再生四肢和器官的能力。

AbstractThis award provides renewed funding for the Indiana University Axolotl Colony, a self-sustaining, breeding colony of the Mexican axolotl (Ambystoma mexicanum). The Colony is a genetic stock center dedicated to the supply of genetically well-characterized axolotl embryos, larvae, and adults to laboratories throughout the United States and abroad. The IU Colony currently provides 50,000 embryonic, larval, juvenile and adult animals to researchers and educators each year.The axolotl, a neotenic salamander, is a non-mammalian model system with a number of features that are advantageous in experimental studies of vertebrate developmental biology, neuroscience, and immunology. These include large oocytes that display lampbrush chromosomes; large, polyspermic eggs that are suitable for nuclear transplantation and that can be easily manipulated to obtain haploids or polyploid embryos; large, accessible embryos that tolerate microsurgery well; large individual nerve cells; and the ability to regenerate limbs and organs.