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Career: Invention and Development of 'Tin-Lite' Reactions for Organic Synthesis

职业：有机合成“Tin-Lite”反应的发明和开发

基本信息

批准号：
9984644
负责人：
Robert Maleczka
金额：
$ 38.36万
依托单位：
Michigan State University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2000
资助国家：
美国
起止时间：
2000-03-01 至 2005-02-28
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9984644&HistoricalAwards=false
关键词：
Career Invention Development Tin Lite

项目摘要

The focus of this research is the development of "Tin-Lite"alternatives to reactions involving organotin chemistry. A practical, tin catalyzed Stille cross-coupling reaction will be developed and the methodology will also be applied to traditional organotin mediated reactions, copper based cross-couplings fluorous phase reactions and combinatorial chemistry. The results could have a broad impact on the commercial synthesis of biologically important compounds. The educational component of the project involves the introduction of high school students to a meaningful laboratory experience and the introduction of a pharmaceutical chemistry course at the undergraduate level.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the research and educational activities of Dr. Robert E.. Maleczka of the Department of Chemistry at Michigan State University. Professor Maleczka will focus his research on the discovery, development and application of stannane mediated reactions in organic synthesis with the specific goal of minimizing the tin requirement in these reactions. The approach will rely on the design of new reactions catalytic in tin and in seeking non-tin alternatives. The methodology has broad implications for synthesis in the pharmaceutical industry. The educational activities of the project include curriculum development and high school outreach.

这项研究的重点是开发“锡建兴“的替代品，涉及有机锡化学反应。一个实用的，锡催化的Stille交叉偶联反应将被开发，该方法也将被应用到传统的有机锡介导的反应，铜基交叉偶联氟相反应和组合化学。这些结果可能对生物重要化合物的商业合成产生广泛的影响。该项目的教育部分涉及高中学生介绍一个有意义的实验室经验，并在本科阶段引入药物化学课程。有了这个职业奖，有机和高分子化学计划支持博士的研究和教育活动。密歇根州立大学化学系的Maleczka说。 Maleczka教授的研究重点是锡烷介导的反应在有机合成中的发现、开发和应用，具体目标是最大限度地减少这些反应中的锡需求。该方法将依赖于设计新的锡催化反应和寻求非锡替代品。该方法具有广泛的影响，在制药工业的合成。该项目的教育活动包括课程编制和高中外联。