NANOSCALE: Nanostructured Biocomposites for Use as Novel Films and Coatings

建议编号：CTS-9986488建议类型：响应NSF 99-109，在Nanoscales对生物系统的探索性研究首席研究员：James F.Rathmanship从属关系：俄亥俄州立大学纳米：用作新型薄膜和涂层的纳米结构生物复合材料这个探索性项目调查了同时包含有机和无机成分的纳米结构复合膜的制备和应用，特别是由二氧化硅基质和含有胶原和纤维连接蛋白的薄膜组成的薄膜。这种薄膜是在液-液界面上合成的，表面活性剂被用来促进自组装和具有有用性能的纳米结构。新型薄膜的三种应用将进行测试。纳米多孔二氧化硅-胶原膜有望具有良好的热稳定性和机械强度。它们将作为保护膜进行测试，以防止有机电致发光显示设备的湿气损害。胶原-二氧化硅复合材料的纤维连接蛋白修饰将作为稳定分子筛的来源进行测试，并将控制孔大小，以提供能够过滤生物过程流中病毒的膜。此外，纤维连接蛋白纽带的能力将被用于微载体中，用于含有锚定依赖细胞的细胞培养。成功地利用这些独特的复合材料获得新的性能可以导致广泛的应用。

AbstractProposal number: CTS-9986488Proposal type: Response to NSF 99-109, Exploratory Research on Biosystems at the NanoscalePrincipal investigator: James F. RathmanAffiliation: Ohio State NANOSCALE: Nanostructured Biocomposites for Use as Novel Films and Coatings This exploratory project investigates the fabrication and applications of nanostructured composite films containing both organic and inorganic components, specifically films consisting of a silica matrix and containing collagen and fibronectin. The films are synthesized at a liquid-liquid interface, and surfactants are used to promote self-assembly and nanostructures with useful properties. Three applications of the new types of films will be tested. Nanoporous silica-collagen films are expected to have good thermal stability and mechanical strength. They will be tested as protective coatings to prevent moisture damage of organic electroluminescent display devices. Fibronectin modification of collagen-silica composites will be tested as a source of stable molecular sieves, and the pore sizes will be controlled to provide membranes that can filter viruses from bioprocess streams. Also, the ability of fibronectin tethers will be exploited in microcarriers for cell cultures containing anchorage-dependent cells. Success in achieving novel properties with these unique composites can lead to a wide variety of applications.