Control of formation of polymorphic molecule crystals

该项目的目的是表征新的亚稳结晶相，并根据选定的有机分子阐明其形成机制。悬浮条件下的过冷熔体和过饱和溶液是形成亚稳晶体的前驱相。我们专注于扩散控制和无扩散结晶过程的影响，以及悬浮条件下表面诱导的多态性和选择性结晶的可能性。计划基于各种实验方法（介电光谱、粉末X射线衍射、拉曼光谱、差示扫描量热法、环境扫描电子显微镜）进行时间分辨原位调查。将研究以下模型系统：卡马西平、对乙酰氨基酚、吲哚美嗪和非洛地平。

The aim of the project is the characterization of novel metastable crystalline phases and the elucidation of their formation mechanism based on selected organic molecules. The super cooled melt and the supersaturated solution under levitation conditions serve as precursor phases for the formation of metastable crystal. We focus on the impact of diffusion controlled and diffusionless crystallization processes as well as the possibility surface induced polymorphism and selective crystallization under levitation conditions. Time resolved in situ investigations based on a variety of experimental methods (Dielectric spectroscopy, Powder X-ray Diffraction, Raman Spectroscopy, Differential Scanning Calorimetry, Environmental Scanning Electron Microscope) are planned. The following model systems will be investigated: carbamazepine, acetaminophen, indomethazin, and felodipine.