Investigation into the Synthesis of Novel Macrocyclic Tetraesters Based on 3,4-Derivatized Tetrahydrofuran Components

化学部颁发的POWRE奖支持Jetty Duffy-Matzner博士在南达科他州苏福尔斯的奥古斯塔纳学院开展小分子杂环化学研究项目。这项研究的目标是合成、表征和测试一系列具有破坏细胞膜上钠和钾浓度差异的潜在能力的聚合物的抗菌活性。该奖项将使Duffy-Matzner博士能够：与奥古斯塔纳学院生物学助理教授Nola Borman博士建立联合合作，探索项目中合成的新型化合物的生物活性；邀请奥古斯塔纳分子模型药物化学课程的高级学生参与；为Duffy-Matzner博士在锡拉丘兹大学无机化学家Karin Ruhlandt-Senger博士的实验室的本科生同事创造暑期研究经验，后者也将在这个项目上与Duffy-Matzner博士合作。这一奖项将大大促进达菲-马茨纳博士的职业发展，目前她正处于职业生涯的关键阶段。

This POWRE award by the Chemistry Division supports Dr. Jetty Duffy-Matzner in developing a research program in small molecule heterocyclic chemistry at Augustana College in Sioux Falls South Dakota. The objective of this research will be to synthesize, characterize and test the antibiotic activity of a series of polymers with the potential ability to disrupt the sodium and potassium concentration differences across cellular membranes. This award will allow Dr. Duffy-Matzner to: establish a joint collaboration with Dr. Nola Borman, Assistant Professor of Biology at Augustana College to explore the biological activities of the novel compounds synthesized in the project; involve advanced students in Augustana's medicinal chemistry course in molecular modelling; create summer research experiences for Dr. Duffy-Matzner's undergraduate student co-workers in the laboratory of Dr. Karin Ruhlandt-Senge, an inorganic chemist at Syracuse University, who will also collaborate with Dr. Duffy-Matzner on this project. This award will contribute significantly to the professional advancement of Dr. Duffy-Matzner, at a critical stage in her career.