NAS Colloquium on Links Between Recombination and Replication: Vital Roles of Recombination; Irvine, California, November 10 - 12, 2000

“重组和复制之间的联系：重组的重要作用”研讨会将于2000年11月10日至12日在加州欧文的阿诺德和梅布尔贝克曼中心举行。与会者将包括遗传学家、生物化学家、物理化学家和分子生物学家。最近在大肠杆菌和酿酒酵母中的例子提供了越来越多的证据，证明重组和复制之间的联系是广泛存在的。现在很清楚的是，复制叉经常停止或断裂，重组酶通过挽救这些叉来防止细胞死亡。这些发现对生物学、医学、工业和农业具有重要意义。对DNA损伤修复中重组功能的充分了解，将有助于进一步了解细胞分裂、对DNA损伤的多种反应以及限制癌变的机制。对于基因靶向的生物技术，也可能发现一些线索。在细菌中，塌陷的复制叉的修复对生存能力有巨大的影响，对此的进一步研究可能为针对细菌感染的治疗提供新的靶点。研讨会的目标是促进对DNA重组和复制之间联系的进一步研究，并提高整个生物医学界的同事和学生对这一发展领域的认识。为了实现这一目标，《美国国家科学院院刊》（Proceedings of the National Academy of Sciences）将以一整期的版面专门刊登这次研讨会的研究报告。

AbstractMCB-0083174FultonThe Colloquium "Links between Recombination and Replication: Vital Roles of Recombination" will be held from Nov. 10-12, 2000, at the Arnold and Mabel Beckman Center in Irvine, California. Attendees will include geneticists, biochemists, physical chemists, and molecular biologists. Recent examples in Escherichia coli and Saccharomyces cerevisiae have provided increasing evidence that links between recombination and replication are widespread. It is now clear that replication forks frequently stall or break, and that recombination enzymes forestall cell death by rescuing those forks. These findings have important implications for biology, medicine, industry and agriculture. A full understanding of the functions of recombination in the repair of damage to DNA will provide further insights into cell division, the multifarious response to DNA damage, and the mechanisms that limit carcinogenesis. Clues may be found as well for the biotechnology of gene targeting. In bacteria, the repair of collapsed replication forks has a dramatic impact on viability, the further study of which may suggest new targets for therapy directed at bacterial infections. The goal of the Colloquium is to stimulate further research on the connections between DNA recombination and replication, and to increase awareness of this developing area among colleagues and students throughout the biomedical community. Toward the achievement of that goal, an entire issue of the Proceedings of the National Academy of Sciences will be devoted to research reports emanating from the Colloquium.