Equipment Proposal: Integrated Optical Force and Near-Field Scanning-Probe Microscope for Polymer Interfaces

设备提案：用于聚合物界面的集成光学力和近场扫描探针显微镜

• 批准号: 0083258
• 负责人: Raj Rajagopalan
• 金额: $ 10万
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-10-01 至 2004-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0083258&HistoricalAwards=false
• 关键词: Equipment; Proposal; Integrated; Optical; Force

NSF CTS 0083258Equipment Proposal: Integrated Optical-Force and Scanning-Probe MicroscopeRaj Rajagopalan, University of FloridaAbstractThe funds requested through this proposal will be used to construct an optical-tweezer-probe for a scanning optical microscope and to add dynamic light scattering peripherals to the instrument. The resulting optical force microscope will be used to study polymer-induced forces at solid-liquid interfaces and to develop techniques for measuring dynamic compliance of polymer layers. The requested additions will enhance the capability of the basic instrument so that a number of related problems, such as mechanical response of oil-surfactant-water interfaces and fluorescent microscopy on single polymer chains, can be studied.The overall objective of this grant is to incorporate a device for "optical manipulation" of small particles in a microscope. A tightly focused laser beam trained on a small particle allows one to manipulate and move the particle using the forces generated by the light beam. The combination of such a "laser tweezer" with a scanning optical microscope allows one to use the optically held particle as a "probe" to study local interactions on a surface. The laser beam holding the particle behaves like an invisible spring on the particle, and the stiffness of this "spring" can be changed easily by adjusting the laser power. Therefore, the optically held probe allows one to study very soft surfaces such as polymer chains on a surface or a liquid/liquid interface. This opens up new ways to study the mechanical and dynamic properties of polymer layers, single polymer chains, surfactants at interfaces, and the like. The implications of such phenomena extend to a number of important problems in engineering and the sciences, such as stability of biological and pharmaceutical dispersions, polymer compatibility with biomedical surfaces, and environmental separation processes involving particulates.

NSF CTS 0083258设备提案：集成光学力和扫描探针显微镜Raj Rajagopalan，佛罗里达大学摘要通过该提案请求的资金将用于构建用于扫描光学显微镜的光镊探针，并向仪器添加动态光散射外围设备。由此产生的光学力显微镜将用于研究固液界面上聚合物引起的力，并开发测量聚合物层动态柔量的技术。所要求的附加功能将增强基本仪器的功能，以便可以研究许多相关问题，例如油-表面活性剂-水界面的机械响应和单聚合物链上的荧光显微镜。这项资助的总体目标是在显微镜中加入一种对小颗粒进行“光学操纵”的装置。将紧密聚焦的激光束照射在小颗粒上，可以利用光束产生的力来操纵和移动颗粒。这种“激光镊子”与扫描光学显微镜的结合允许人们使用光学保持的粒子作为“探针”来研究表面上的局部相互作用。固定颗粒的激光束就像颗粒上看不见的弹簧一样，并且可以通过调整激光功率轻松改变这个“弹簧”的刚度。因此，光学固定探针允许研究非常柔软的表面，例如表面或液/液界面上的聚合物链。这开辟了研究聚合物层、单聚合物链、界面表面活性剂等的机械和动态特性的新方法。这种现象的影响延伸到工程和科学中的许多重要问题，例如生物和药物分散体的稳定性、聚合物与生物医学表面的相容性以及涉及颗粒的环境分离过程。