Mouse Mutant Stocks Center

该奖项为杰克逊实验室（TJL）的小鼠突变种群中心（MMSC）提供了新的支持。 多年来，实验室小鼠（Mus musculus）一直是用于脊椎动物实验遗传学研究的主要模式生物。MMSC维护并向科学界分发小家鼠和其他几种小鼠的突变种群，并发现和描述科学界可能感兴趣的新的自发小鼠突变。该集合目前包含109个股票和近交系携带125个自发突变的定义的遗传背景，18个近交系的专业菌株来自野生种群，和13个近交系和F1杂交种。 突变株的培育数量足以满足其在研究中的使用需求;此外，所有菌株都保存为冷冻胚胎和基因组DNA。 作为其发现计划的一部分，MMSC确定了大型TJL育种菌落中出现的新的自发突变;由于它们的大小，这些菌落提供了丰富的新突变来源。突变最初通过其对外观或行为的影响来识别。 进一步的表征包括评估突变的遗传模式和染色体位置，以及通过基因型和表型特性判断其对基础研究的潜在价值。 MMSC通过实验室的目录、特别通讯和网站提供关于已建立和新开发的突变体的信息。向MMSC申请一个或多个突变小鼠种群的研究人员会被收取一定的费用，部分原因是维持所申请的特定品系的难度和费用。

This award provides renewed support for the Mouse Mutant Stocks Center (MMSC) at The Jackson Laboratory (TJL). For many years, the laboratory mouse (Mus musculus) has been the principal model organism used for experimental genetic studies of vertebrate animals. The MMSC maintains and distributes mutant stocks of Mus musculus and several other species of Mus to the scientific community, and also discovers and characterizes new spontaneous mouse mutations of potential interest to the scientific community. The collection currently contains 109 stocks and inbred strains carrying 125 spontaneous mutations on defined genetic backgrounds, 18 inbred specialty strains derived from wild populations, and 13 inbred strains and F1 hybrids. Mutant strains are bred in sufficient number to meet the demand for their use in research; in addition, all strains are preserved as frozen embryos and as genomic DNA. As part of its discovery program, the MMSC identifies new spontaneous mutations arising in the large TJL breeding colonies; because of their size, these colonies provide a rich source of new mutations. Mutations are initially identified by their effect on appearance or behavior. Further characterization includes assessment of the mutation's inheritance pattern and chromosomal location, as well as its potential value for basic research as judged by genotypic and phenotypic properties. The MMSC provides information about established and newly developed mutants through the Laboratory's catalog, special newsletters and Web site. Researchers who request one or more stocks of mutant mice from the MMSC are charged a modest fee based in part on the difficulty and expense of maintaining the particular lines requested.