Microbial Ecology and Genomics: Understanding the Patterns and Processes of Single Cells, Communities and the Ecosphere; February 23-25, 2001 in Southern California

[00:907 . 11]现在我们知道，培养出来的微生物物种很难代表它们的自然多样性，这使为可见世界建立的惯例相形见绌。在过去的十年中，利用更新的分子工具探索环境多样性揭示了这一点，并引发了微生物生态学和技术的爆炸式增长，这些技术可能受益于自然生物化学多样性的恩惠。几次座谈会和会议帮助制定了政策建议，使这些领域的研究项目能够持续下去。提议的研讨会的主要目标是提供一个论坛来讨论最近显现出来的科学机遇和研究挑战。我们如何将基因组序列信息带回环境？环境是基因组进化、发挥功能并继续进化的环境。这是他们能被完全理解的唯一环境。我们建议明确评估微生物系统学可能的新作用。微生物系统学在为现在产生的大量基因组信息提供秩序方面将发挥什么作用？基因组信息在环境中是如何包装的？基因组序列与表型之间的关系是什么？关于进化和适应性辐射的基本机制，比较基因组学告诉了我们什么？在我们能够在这一领域取得进展之前，必须解决这些问题。

0090711ColganIt is now known that microbial species in culture poorly represent their natural diversity-which dwarfs conventions established for the visible world. This was revealed over the last decade using newer molecular tools to explore environmental diversity and has sparked an explosive growth in microbial ecology and technologies that may profit from the bounty of natural biochemical diversity. Several colloquia and meetings have helped formulate policy recommendations to enable sustained research programs in these areas.The primary objective of the proposed workshop is to provide a forum to address science opportunities and research challenges recently made evident. How will we take genome sequence information back to the environment? The environment is the context in which genomes evolved, function, and continue to evolve. It is the only context in which they can be fully understood. We suggest that we explicitly evaluate possible new roles of microbial systematics. What role will microbial systematics play in providing order to the immense amount of genomic information now being generated? How is genomic information packaged in the environment? What is the relationship between genome sequence and phenotype? What is comparative genomics telling us about the basic mechanisms of evolution and adaptive radiation? These questions must be addressed before we can move forward in this field.