Star Porphyrazines

星形紫菜嗪

• 批准号: 0091364
• 负责人: Brian Hoffman
• 金额: $ 54.57万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-15 至 2004-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0091364&HistoricalAwards=false
• 关键词: Star; Porphyrazines

The Inorganic, Bioinorganic and Organometallic Chemistry Program of the Division of Chemistry, National Science Foundation, supports the work of Dr. Brian Hoffman (as the PI) of the Department of Chemistry at Northwestern University, and Anthony Barrett (as co-PI) of Imperial College, London UK, for their collaborative work on star porphyrazines (pzs). Specifically, they will (i) investigate multi-metallic pzs and pz multimers that will exhibit macrocycle-mediated spin coupling among the localized moments in the metal ions; (ii) examine porphyrazine assemblies and metal-linked pz ribbons that incorporate redox-switchable conduction and/or spin coupling; (iii) explore metal-porphyrazine systems as contrast agents in optical tumor imaging; (iv) examine charged pzs containing an active central metal ion (e.g. Fe or Mn) as possible catalysts for peroxynitrite decomposition; and (v) explore the usefulness of porphyrazines with peripheral substituents designed to bind redox-active metals in applications as sol-gel incorporated optical sensors and/or as dual opto/electrochemical metal-ion sensors.The work supported by this award will have significant impact on a variety of scientific and technological applications. The class of compounds known as star porphyrazines will be highly useful as contrast agents in bio-imaging of tumors, and in such applications as sol-gel incorporated optical sensors and/or as dual opto/electrochemical metal-ion sensors. Students and post-doctoral associates will gain fundamental and diverse skills not only in syntheses and physical characterization of these compounds, but also in exploring the potential application of the resulting products in catalysis, bio-imaging, and sensors.

美国国家科学基金会化学部的无机、生物无机和有机化学项目支持西北大学化学系的Brian霍夫曼博士（作为PI）和英国伦敦帝国理工学院的Anthony Barrett（作为共同PI）在星星卟啉（pzs）方面的合作工作。具体来说，他们将（i）研究多金属pz和pz多聚体，这些多金属pz和pz多聚体将在金属离子的局部矩之间表现出大环介导的自旋耦合;（ii）研究卟啉组装体和金属连接的pz带，这些pz带包含氧化还原可切换的传导和/或自旋耦合;（iii）探索金属-卟啉系统作为光学肿瘤成像中的造影剂;（iv）检查含有活性中心金属离子的带电PZ（例如Fe或Mn）作为过氧亚硝酸盐分解的可能催化剂;和（v）探索具有设计成结合氧化还原活性金属的外围取代基的四氮杂卟啉在作为溶胶-凝胶结合的光学传感器和/或作为双光/光电传感器的应用中的有用性。该奖项支持的工作将对各种科学和技术应用产生重大影响。被称为星星卟啉的这类化合物将在肿瘤的生物成像中作为造影剂，并且在诸如溶胶-凝胶结合的光学传感器和/或作为双光/电化学金属离子传感器的应用中非常有用。学生和博士后将获得基本和多样化的技能，不仅在这些化合物的合成和物理表征，而且在探索所得产品在催化，生物成像和传感器的潜在应用。