Vibrational Spectral Studies

振动光谱研究

• 批准号: 0092922
• 负责人: Prasad Polavarapu
• 金额: $ 30.1万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0092922&HistoricalAwards=false
• 关键词: Vibrational; Spectral; Studies

Prasad L. Polavarapu of Vanderbilt University has support from the Experimental Physical Chemistry Program to continue his spectral studies using vibrational circular dichroism. During the three-year award period, he will undertake the following investigations: a) the elucidation of guest-host interactions for molecules encapsulated in cyclodextrin cavities; b) the determination of absolute configuration of chiral suboxides; c) the determination of structural changes in peptides; d) the determination of the structure of bioactive peptides in membrane environments; e) the structural characterization of peptides that adopt b-hairpin structures; and f) the determination of conformations of chiral herbicides. The principal investigator will also undertake ab initio theoretical calculations in order to fully analyze the experimental observations. These studies will advance knowledge and understanding in a number of fields: chemical, biochemical and environmental. The activities will not only advance scientific knowledge in these areas but also promote training, teaching and learning. One of the more practical impacts of this work will be in the development and design of new herbicides with greater specificity and cost-effectiveness.

范德比尔特大学的Prasad L. Polavarapu得到了实验物理化学项目的支持，继续使用振动圆二色性进行光谱研究。在三年的奖励期内，他将进行以下研究：a)阐明包裹在环糊精腔中的分子的主客相互作用；B)测定手性亚氧化物的绝对构型；C)多肽结构变化的测定；D)膜环境中生物活性肽结构的测定；E)采用b-发夹结构的肽的结构表征；f)手性除草剂构象的测定。首席研究员还将进行从头理论计算，以便充分分析实验观察结果。这些研究将促进对化学、生化和环境等多个领域的认识和理解。这些活动不仅将促进这些领域的科学知识，而且还将促进培训、教学和学习。这项工作的一个更实际的影响将是开发和设计具有更高特异性和成本效益的新除草剂。