Vibrational Spectral Studies

普拉萨德湖范德比尔特大学的Polavarapu得到了实验物理化学计划的支持，继续使用振动圆二色性进行光谱研究。 在为期三年的研究期内，他将进行以下研究：a）环糊精空腔中分子的客体-主体相互作用的阐明; B）手性低氧化物绝对构型的测定; c）肽结构变化的测定; d）膜环境中生物活性肽结构的测定; e）采用b-发夹结构的肽的结构表征;和f）手性除草剂构象的测定。 首席研究员还将进行从头计算理论计算，以充分分析实验观察结果。 这些研究将促进化学、生物化学和环境等领域的知识和理解。 这些活动不仅将促进这些领域的科学知识，而且还将促进培训、教学和学习。 这项工作更实际的影响之一将是开发和设计具有更大特异性和成本效益的新除草剂。

Prasad L. Polavarapu of Vanderbilt University has support from the Experimental Physical Chemistry Program to continue his spectral studies using vibrational circular dichroism. During the three-year award period, he will undertake the following investigations: a) the elucidation of guest-host interactions for molecules encapsulated in cyclodextrin cavities; b) the determination of absolute configuration of chiral suboxides; c) the determination of structural changes in peptides; d) the determination of the structure of bioactive peptides in membrane environments; e) the structural characterization of peptides that adopt b-hairpin structures; and f) the determination of conformations of chiral herbicides. The principal investigator will also undertake ab initio theoretical calculations in order to fully analyze the experimental observations. These studies will advance knowledge and understanding in a number of fields: chemical, biochemical and environmental. The activities will not only advance scientific knowledge in these areas but also promote training, teaching and learning. One of the more practical impacts of this work will be in the development and design of new herbicides with greater specificity and cost-effectiveness.