CAREER: A Novel Liquid Crystal System for Capillary Electrophoresis

职业：用于毛细管电泳的新型液晶系统

• 批准号: 0094121
• 负责人: Lisa Holland
• 金额: $ 49.5万
• 依托单位: Kent State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-15 至 2003-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0094121&HistoricalAwards=false
• 关键词: CAREER; Novel; Liquid; Crystal; System

Professor Lisa A. Holland of Kent State University is funded by the Analytical and Surface Chemistry CAREER program to study phospholipid bicelles as immobilized partitioning media for electrokinetic capillary chromotography. The work involves the characterization of the bicelle media in detail as a function of temperature, mixed micelle ratios, concentration and composition. Then the sieving capabilities of this material will be optimized for separation of polypeptides, proteins and DNA. The ability of bicelle solutions to incorporate receptor systems based on biotin-avidin chemistry will be utilized. The educational component of this work focuses on the use of distance learning to initiate a research program in separations at Haskell Indian Nations University. The interest is in screening traditional tribal medicines for receptor affinity.

肯特州立大学的Lisa A.Holland教授是由分析和表面化学职业生涯计划资助的，研究作为电动毛细管色谱固定化分配介质的磷脂双分子。这项工作包括详细地表征双胶束介质作为温度、混合胶束比例、浓度和组成的函数。然后，这种材料的筛分能力将被优化，以分离多肽、蛋白质和DNA。将利用双通道溶液结合基于生物素-亲和素化学的受体系统的能力。这项工作的教育部分侧重于利用远程学习在哈斯克尔印第安人民族大学发起一项关于分离的研究方案。他们感兴趣的是筛选传统部落药物的受体亲和力。